Leonardi Natalia M, Tesán Fiorella C, Zubillaga Marcela B, Salgueiro María J
Radioisotope Laboratory, Physics Department, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina.
Radioisotope Laboratory, Physics Department, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
J Nucl Med Technol. 2014 Dec;42(4):292-5. doi: 10.2967/jnmt.114.144303. Epub 2014 Oct 23.
In accord with as-low-as-reasonably-achievable and good-manufacturing-practice concepts, the present study evaluated the efficiency of radioactivity decontamination of materials commonly used in laboratory surfaces and whether solvent spills on these materials affect the findings.
Four materials were evaluated: stainless steel, a surface comprising one-third acrylic resin and two-thirds natural minerals, an epoxy cover, and vinyl-based multipurpose flooring. Radioactive material was eluted from a (99)Mo/(99m)Tc generator, and samples of the surfaces were control-contaminated with 37 MBq (100 μL) of this eluate. The same procedure was repeated with samples of surfaces previously treated with 4 solvents: methanol, methyl ethyl ketone, acetone, and ethanol. The wet radioactive contamination was allowed to dry and then was removed with cotton swabs soaked in soapy water. The effectiveness of decontamination was defined as the percentage of activity removed per cotton swab, and the efficacy of decontamination was defined as the total percentage of activity removed, which was obtained by summing the percentages of activity in all the swabs required to complete the decontamination.
Decontamination using our protocol was most effective and most efficacious for stainless steel and multipurpose flooring. Moreover, treatment with common organic solvents seemed not to affect the decontamination of these surfaces. Decontamination of the other two materials was less efficient and was interfered with by the organic solvents; there was also great variability in the overall results obtained for these other two materials.
In expanding our laboratory, it is possible for us to select those surface materials on which our decontamination protocol works best.
根据尽可能低合理可行原则和良好生产规范概念，本研究评估了实验室表面常用材料的放射性去污效率，以及这些材料上的溶剂泄漏是否会影响研究结果。
评估了四种材料：不锈钢、一种由三分之一丙烯酸树脂和三分之二天然矿物质组成的表面、环氧涂层以及乙烯基地面材料。从（99）钼/（99m）锝发生器中洗脱放射性物质，并用37MBq（100μL）该洗脱液对表面样本进行对照污染。对预先用4种溶剂处理过的表面样本重复相同程序：甲醇、甲乙酮、丙酮和乙醇。让湿的放射性污染物干燥，然后用浸有肥皂水的棉签去除。去污效果定义为每根棉签去除的活度百分比，去污效能定义为去除的活度总百分比，通过将完成去污所需的所有棉签中的活度百分比相加获得。
使用我们的方案进行去污对不锈钢和多功能地板最有效且效能最高。此外，用常见有机溶剂处理似乎不会影响这些表面的去污。其他两种材料的去污效率较低，且受到有机溶剂的干扰；这两种材料的总体结果也存在很大差异。
在扩大我们的实验室时，我们有可能选择那些我们的去污方案效果最佳的表面材料。
