Li Ming, Guo Kequan, Ikehara Susumu
Department of Stem Cell Disorders, Kansai Medical University, 2-5-1 Shinmachi, Hirakata City, Osaka 573-1010, Japan.
Department of Cardiac Surgery, Beijing Institute of Heart, Lung & Blood Vessel Disease, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing 100029, China.
Int J Mol Sci. 2014 Oct 23;15(10):19226-38. doi: 10.3390/ijms151019226.
Alzheimer's disease (AD) is a progressive and neurodegenerative disorder that induces dementia in older people. It was first reported in 1907 by Alois Alzheimer, who characterized the disease as causing memory loss and cognitive impairment. Pathologic characteristics of AD are β-amyloid plaques, neurofibrillary tangles and neurodegeneration. Current therapies only target the relief of symptoms using various drugs, and do not cure the disease. Recently, stem cell therapy has been shown to be a potential approach to various diseases, including neurodegenerative disorders, and in this review, we focus on stem cell therapies for AD.
阿尔茨海默病（AD）是一种进行性神经退行性疾病，可导致老年人痴呆。1907年，阿洛伊斯·阿尔茨海默首次报告了该病，他将其特征描述为导致记忆丧失和认知障碍。AD的病理特征是β-淀粉样蛋白斑块、神经原纤维缠结和神经退行性变。目前的治疗仅使用各种药物来缓解症状，无法治愈该疾病。最近，干细胞疗法已被证明是治疗包括神经退行性疾病在内的各种疾病的一种潜在方法，在本综述中，我们重点关注AD的干细胞疗法。
Zotero 插件