de Rezende Victória Linden, de Aguiar da Costa Maiara, Martins Carla Damasio, Mathias Khiany, Gonçalves Cinara Ludvig, Barichello Tatiana, Petronilho Fabricia
Laboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil.
Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Health Sciences Unit, University of South Santa Catarina, Tubarao, SC, Brazil.
Neurochem Res. 2025 Mar 4;50(2):112. doi: 10.1007/s11064-025-04361-7.
The aging process results in structural, functional, and immunological changes in the brain, which contribute to cognitive decline and increase vulnerability to neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and stroke-related complications. Aging leads to cognitive changes and also affect executive functions. Additionally, it causes neurogenic and neurochemical alterations, such as a decline in dopamine and acetylcholine levels, which also impact cognitive performance. The chronic inflammation caused by aging contributes to the impairment of the blood-brain barrier (BBB), contributing to the infiltration of immune cells and exacerbating neuronal damage. Therefore, rejuvenating therapies such as heterochronic parabiosis, cerebrospinal fluid (CSF) administration, plasma, platelet-rich plasma (PRP), and stem cell therapy have shown potential to reverse these changes, offering new perspectives in the treatment of age-related neurological diseases. This review focuses on highlighting the effects of rejuvenating interventions on neuroinflammation and the BBB.
衰老过程会导致大脑出现结构、功能和免疫方面的变化，这些变化会导致认知能力下降，并增加患神经退行性疾病（如阿尔茨海默病（AD）、帕金森病（PD）和中风相关并发症）的易感性。衰老会导致认知变化，还会影响执行功能。此外，它会引起神经发生和神经化学改变，如多巴胺和乙酰胆碱水平下降，这也会影响认知表现。衰老引起的慢性炎症会导致血脑屏障（BBB）受损，促使免疫细胞浸润并加剧神经元损伤。因此，诸如异时联体共生、脑脊液（CSF）输注、血浆、富血小板血浆（PRP）和干细胞疗法等恢复活力的疗法已显示出逆转这些变化的潜力，为治疗与年龄相关的神经疾病提供了新的视角。这篇综述着重强调恢复活力干预措施对神经炎症和血脑屏障的影响。
