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干细胞疗法治疗和管理阿尔茨海默病的综合综述。

A consolidated review on stem cell therapy for treatment and management of Alzheimer's disease.

作者信息

Ahmad Faizan, Sachdeva Punya

机构信息

Department of Medical Elementology and Toxicology Jamia Hamdard University Delhi India.

Amity Institute of Neuropsychology and Neurosciences Amity University Noida Uttar Pradesh India.

出版信息

Aging Med (Milton). 2022 Jul 25;5(3):182-190. doi: 10.1002/agm2.12216. eCollection 2022 Sep.

Abstract

Alzheimer's disease (AD) is one of the most common forms of dementia and affects around 50 million people around the globe. AD is diagnosed mainly through imaging techniques and to date only five drugs are approved for management of AD but no promising treatment is available for AD. So in this review, we are focusing on stem cell therapy for AD. This review will cover all stem cells like mesenchymal stem cells, embryonic stem cells, induced pluripotent stem cells, and neural stem cells. Clinical trials of AD have also been discussed. Finally, limitations of stem cells are discussed with ongoing clinical trials, and in the future stem cell therapy can be used for treatment of AD.

摘要

阿尔茨海默病(AD)是最常见的痴呆形式之一,全球约有5000万人受其影响。AD主要通过成像技术进行诊断,迄今为止仅有五种药物被批准用于AD的治疗,但尚无有效的AD治疗方法。因此,在本综述中,我们将重点关注AD的干细胞治疗。本综述将涵盖所有干细胞,如间充质干细胞、胚胎干细胞、诱导多能干细胞和神经干细胞。文中还讨论了AD的临床试验。最后,结合正在进行的临床试验讨论了干细胞的局限性,未来干细胞治疗可用于AD的治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/983b/9549310/bdd1270acee9/AGM2-5-182-g001.jpg

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