Meir Rinat, Motiei Menachem, Popovtzer Rachela
Bar-Ilan University, Faculty of Engineering & the Institute of Nanotechnology & Advanced Materials, Ramat Gan 52900, Israel.
Nanomedicine (Lond). 2014 Sep;9(13):2059-69. doi: 10.2217/nnm.14.129.
Cell-based therapy offers a promising solution for the treatment of diseases and injuries that conventional medicines and therapies cannot cure effectively, and thus comprises an encouraging arena for future medical breakthroughs. The development of an accurate and quantitative noninvasive cell tracking technique is a highly challenging task that could help in evaluating the effectiveness of treatments. Moreover, cell tracking could provide essential knowledge regarding the fundamental trafficking patterns and poorly understood mechanisms underlying the success or failure of cell therapy. This article focuses on gold nanoparticles, which provide cells with 'visibility' in a variety of imaging modalities for stem cell therapy, immune cell therapy and cancer treatment. Current challenges and future prospects relating to the use of gold nanoparticles in such roles are discussed.
基于细胞的疗法为治疗传统药物和疗法无法有效治愈的疾病和损伤提供了一个有前景的解决方案，因此是未来医学突破的一个令人鼓舞的领域。开发一种准确且定量的非侵入性细胞追踪技术是一项极具挑战性的任务，它有助于评估治疗效果。此外，细胞追踪可以提供有关基本运输模式以及细胞治疗成败背后知之甚少的机制的重要知识。本文重点关注金纳米颗粒，它能在多种成像方式中为干细胞治疗、免疫细胞治疗和癌症治疗的细胞提供“可视性”。讨论了在这些应用中使用金纳米颗粒目前面临的挑战和未来前景。
