Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan Department of Neurology, Neurology Chiba Clinic, Chiba, Japan.
J Neurol Neurosurg Psychiatry. 2015 Jun;86(6):695-7. doi: 10.1136/jnnp-2014-309232. Epub 2014 Oct 24.
High mobility group box 1 (HMGB1) functions as an inflammatory mediator and is implicated in the pathogenesis of various autoimmune diseases. Our primary aim is to determine whether HMGB1 is involved in the pathogenesis of myasthenia gravis (MG).
Serum HMGB1 levels of 60 patients with anti-acetylcholine receptor (AChR) antibody-positive MG without immunosuppressive treatment and of 10 patients with anti-muscle-specific receptor tyrosine kinase (MuSK) antibody-positive MG were compared with those in 40 controls. We also investigated the potential correlation between serum HMGB1 levels and the clinical variables in patients with MG.
Serum HMGB1 levels in patients with anti-AChR antibody-positive MG were higher than those in controls (7.80 ± 7.47 vs 4.13 ± 2.55 ng/mL, p=0.004) and were decreased after treatment (p=0.051). Although not significant, patients with anti-MuSK antibody-positive MG showed higher serum HMGB1 levels than the controls (p=0.178). There were correlations between serum HMGB1 levels and phenotypes of anti-AChR antibody-positive MG: patients with generalised MG showed higher HMGB1 levels than those of patients with ocular MG (p=0.059) and controls (p=0.002); patients with thymoma showed higher HMGB1 levels than those without thymoma (p=0.094) and controls (p=0.001).
Serum HMGB1 is elevated in patients with MG and may play a key role in the inflammation of the neuromuscular junction.
高迁移率族蛋白 B1（HMGB1）作为一种炎症介质，参与多种自身免疫性疾病的发病机制。我们的主要目的是确定 HMGB1 是否参与重症肌无力（MG）的发病机制。
比较 60 例未经免疫抑制治疗的抗乙酰胆碱受体（AChR）抗体阳性 MG 患者和 10 例抗肌肉特异性受体酪氨酸激酶（MuSK）抗体阳性 MG 患者与 40 例对照者的血清 HMGB1 水平。我们还研究了血清 HMGB1 水平与 MG 患者临床变量之间的潜在相关性。
抗 AChR 抗体阳性 MG 患者的血清 HMGB1 水平高于对照组（7.80±7.47 比 4.13±2.55ng/mL，p=0.004），治疗后降低（p=0.051）。虽然不显著，但抗 MuSK 抗体阳性 MG 患者的血清 HMGB1 水平高于对照组（p=0.178）。血清 HMGB1 水平与抗 AChR 抗体阳性 MG 的表型之间存在相关性：全身型 MG 患者的 HMGB1 水平高于眼肌型 MG 患者（p=0.059）和对照组（p=0.002）；合并胸腺瘤的患者 HMGB1 水平高于无胸腺瘤患者（p=0.094）和对照组（p=0.001）。
MG 患者的血清 HMGB1 水平升高，可能在神经肌肉接头炎症中起关键作用。
