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抗肿瘤反应中表型和功能不同的T细胞亚群。

Phenotypically and functionally distinct T-cell subsets in anti-tumor responses.

作者信息

Hamaoka T, Fujiwara H

机构信息

Department of Oncogenesis, Institute for Cancer Research, Osaka University Medical School, 1-1-50, Fukushima, Fukushima-ku, 553, Japan.

出版信息

Immunol Today. 1987;8(9):267-9. doi: 10.1016/0167-5699(87)90186-1.

DOI:10.1016/0167-5699(87)90186-1
PMID:25344282
Abstract

Helper T cells and cytolytic T cells have both been implicated in tumor cell rejection in vivo but their roles and relative importance are still controversial. Here, Toshiyuki Hamaoka and Hiromi Fujiwara discuss recent experiments which suggest that tumor cell growth can be inhibited nonspecifically by the action of gamma interferon as well as by cytolysis and that immunized cells of both 'cytotoxic cell' and 'helper cell' phenotype can produce this lymphokine.

摘要

辅助性T细胞和细胞毒性T细胞在体内肿瘤细胞排斥反应中均有涉及，但它们的作用和相对重要性仍存在争议。在此，滨冈俊之（Toshiyuki Hamaoka）和藤原博美（Hiromi Fujiwara）讨论了近期的实验，这些实验表明，γ干扰素的作用以及细胞溶解作用可非特异性地抑制肿瘤细胞生长，并且具有“细胞毒性细胞”和“辅助细胞”表型的免疫细胞均可产生这种淋巴因子。

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