Sheikh Mashhood Ahmed, Lund Eiliv, Braaten Tonje
Institute of Community Medicine, University of Tromsø, N-9037 Tromsø, Norway.
Lipids Health Dis. 2014 Oct 24;13:164. doi: 10.1186/1476-511X-13-164.
Several studies have analyzed the association of body mass index (BMI) with either the prevalence or incidence of type 2 diabetes (T2D), but no study from Europe or North America has yet analyzed and compared the association of BMI with both incident and prevalent T2D cases.
Stratified logistic regression was used to calculate odds ratios (OR), and stratified Cox proportional hazards regression was used to calculate hazard ratios (HR) of the effect of BMI on the prevalence, and incidence of T2D. Wald chi-square statistics were applied when comparing the risk estimates.
Among prevalent T2D cases, overweight women (BMI 25-29.9 kg/m2) had an OR of 2.83 (95% confidence interval [CI], 1.92-4.18) and obese women (BMI ≥30 kg/m2) had an OR of 12.12 (95% CI, 8.32-17.68) when compared with normal weight women (BMI <25 kg/m2). Among incident T2D cases, overweight women had a HR of 5.01 (95% CI, 3.59-6.98) and obese women had a HR of 15.99 (95% CI, 11.39-22.46) when compared with normal weight women. After stratification by level of physical activity, and adjustment for age, smoking status, and education level, the Wald chi-square statistic for BMI was 180.90 for prevalent T2D cases, and 262.03 for incident T2D cases.
The predictive effect of BMI was found to be stronger for T2D incidence than T2D prevalence.
多项研究分析了体重指数（BMI）与2型糖尿病（T2D）患病率或发病率之间的关联，但来自欧洲或北美的研究尚未分析和比较BMI与T2D新发病例和现患病例的关联。
采用分层逻辑回归计算比值比（OR），采用分层Cox比例风险回归计算BMI对T2D患病率和发病率影响的风险比（HR）。比较风险估计值时应用Wald卡方统计量。
在T2D现患病例中，超重女性（BMI 25 - 29.9 kg/m²）与正常体重女性（BMI <25 kg/m²）相比，OR为2.83（95%置信区间[CI]，1.92 - 4.18），肥胖女性（BMI≥30 kg/m²）的OR为12.12（95% CI，8.32 - 17.68）。在T2D新发病例中，超重女性与正常体重女性相比，HR为5.01（95% CI，3.59 - 6.98），肥胖女性的HR为15.99（95% CI，11.39 - 22.46）。按体力活动水平分层并对年龄、吸烟状况和教育水平进行调整后，BMI的Wald卡方统计量在T2D现患病例中为180.90，在T2D新发病例中为262.03。
发现BMI对T2D发病率的预测作用强于对T2D患病率的预测作用。
