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[遗传性葡萄糖-6-磷酸脱氢酶缺乏症患者的肺结核]

[Pulmonary tuberculosis in patients with hereditary glucose-6-phosphate dehydrogenase deficiency].

作者信息

Insanov A B, Abdullaev F M, Ragimov A A, Talybova A M, Umniashkin A A

出版信息

Ter Arkh. 1989;61(11):75-7.

PMID:2534443
Abstract

A study was made of the occurrence of glucose-6-phosphate dehydrogenase (G-6-PDH) deficiency among patients with lung tuberculosis including those suffering from mental diseases (alcoholism or schizophrenia). In Azerbaijani patients, the rate of G-6-PDH demonstration was higher as compared to that among the healthy population. On combined lung tuberculosis and alcoholism the rate of that abnormality demonstration increased whereas on associated lung tuberculosis and schizophrenia, it slightly decreased. Among patients with hereditary G-6-PDH deficiency, the portion of chronic destructive forms of pulmonary tuberculosis is high, the tuberculous process is accompanied more often by isolation of M. tuberculosis. The etiological role of G-6-PDH as a genetic marker is evaluated as 14%; in associated lung tuberculosis and alcoholism, it grows to 18%.

摘要

对包括患有精神疾病(酗酒或精神分裂症)的肺结核患者中葡萄糖 - 6 - 磷酸脱氢酶(G - 6 - PDH)缺乏症的发生情况进行了研究。在阿塞拜疆患者中,G - 6 - PDH显示率高于健康人群。合并肺结核和酗酒时,该异常显示率增加,而合并肺结核和精神分裂症时,该显示率略有下降。在遗传性G - 6 - PDH缺乏症患者中,慢性破坏性肺结核形式的比例较高,结核过程更常伴有结核分枝杆菌的分离。G - 6 - PDH作为遗传标记的病因学作用评估为14%;在合并肺结核和酗酒时,该比例增至18%。

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