Sommer Doron D, Hoffbauer Stephanie, Au Michael, Sowerby Leigh J, Gupta Michael K, Nayan Smriti
Division of Otolaryngology-Head and Neck Surgery, McMaster University, Hamilton, Canada.
Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Canada.
Otolaryngol Head Neck Surg. 2015 Jan;152(1):42-7. doi: 10.1177/0194599814555836. Epub 2014 Oct 24.
Aspirin exacerbated respiratory disease (AERD) is comprised of aspirin/acetylsalicylic acid (ASA) sensitivity, bronchial asthma, and nasal polyposis. Treatment of this condition is challenging and may include topical/systemic steroids, endoscopic sinus surgery, and/or aspirin desensitization.
A prospective crossover pilot study (n = 10) was conducted in which patients were randomized into either of 2 groups with 6 weeks of regular diet (R) or 6 weeks of a low salicylate diet (LS).
The study was conducted in a tertiary otolaryngology clinic.
Patients with AERD were enrolled in the study.
Subjective (Sino-nasal Outcome Test-22 [SNOT-22], Nasal Sinus Symptom Scale [NSSS], and the Asthma Control Questionnaire-7 [ACQ-7]) and objective outcome instruments (Peri-Operative Sinus Evaluation [POSE] and Lund-Kennedy Endoscopic Score [LKES]) were used to evaluate patients at baseline, 6 weeks (at crossover), and 12 weeks.
Wilcoxon rank sum tests demonstrated that patients on the low salicylate diet had improved scores compared to their regular diet when evaluated by 4 of the 5 outcome measures (SNOT-22 pLS = 0.0059, NSSS pLS = 0.0195, LKES pLS = 0.0039, POSE pLS = 0.005).
Results of the pilot study indicate that implementation of a low salicylate diet improves the nasal symptoms and nasal endoscopy findings of individuals with AERD. Further research is required to support these findings.
阿司匹林诱发的呼吸道疾病（AERD）由阿司匹林/乙酰水杨酸（ASA）敏感、支气管哮喘和鼻息肉病组成。这种疾病的治疗具有挑战性，可能包括局部/全身用类固醇、鼻内镜鼻窦手术和/或阿司匹林脱敏治疗。
进行了一项前瞻性交叉试点研究（n = 10），将患者随机分为两组，一组进行6周的常规饮食（R），另一组进行6周的低水杨酸盐饮食（LS）。
该研究在一家三级耳鼻喉科诊所进行。
纳入了患有AERD的患者。
使用主观（鼻窦结局测试-22 [SNOT-22]、鼻鼻窦症状量表[NSSS]和哮喘控制问卷-7 [ACQ-7]）和客观结局指标（围手术期鼻窦评估[POSE]和伦德-肯尼迪内镜评分[LKES]）在基线、6周（交叉时）和12周时对患者进行评估。
威尔科克森秩和检验表明，在5项结局指标中的4项评估中，与常规饮食相比，低水杨酸盐饮食的患者得分有所改善（SNOT-22 pLS = 0.0059，NSSS pLS = 0.0195，LKES pLS = 0.0039，POSE pLS = 0.005）。
试点研究结果表明，实施低水杨酸盐饮食可改善AERD患者的鼻部症状和鼻内镜检查结果。需要进一步的研究来支持这些发现。
