Department of Otolaryngology - Head & Neck Surgery, Schulich Medicine & Dentistry, Western University, London Health Sciences Centre, St. Joseph's Hospital, London, Ontario, Canada.
Department of Medicine, Western University, London, ON, Canada.
J Otolaryngol Head Neck Surg. 2021 Apr 23;50(1):27. doi: 10.1186/s40463-021-00502-4.
Aspirin-exacerbated respiratory disease (AERD) is characterized by eosinophilic rhinosinusitis, nasal polyposis, and bronchial asthma, along with the onset of respiratory reactions after the ingestion of nonsteroidal anti-inflammatory drugs (NSAIDs) or acetylsalicylic acid (ASA). In addition to the therapeutic routines and surgical options available, a low dietary intake of food salicylate has been suggested as adjunctive therapy for this condition. This study aimed to assess the influence of a short-term low salicylate diet on inflammatory markers in patients with AERD and whether that would result in symptomatic improvement.
Prospective study with randomization to either a high or low salicylate diet for 1 week, followed by cross-over to the other study arm. Participants were asked to record their dietary salicylate for each week of the study. Urinary creatinine, salicylate and leukotriene levels were measured at the time of recruitment, end of week one and end of week two and the SNOT-22 questionnaire was filled out at the same time points.
A total of seven participants completed the study. There was no statistical difference in the urinary salicylate and leukotriene levels between the two diets; nevertheless, participants on low salicylate diet reported improved SNOT-22 symptoms scores (p = 0.04), mainly in the rhinologic, ear/facial, and sleep dysfunction symptom domains. In addition, these last two domains outcomes were more significant than the minimal clinically important difference.
A short-term low salicylate diet may not result in biochemical outcomes changes but seems to provide significant symptomatic relief for patients with AERD.
NCT01778465 ( www.clinicaltrials.gov ).
阿司匹林加重性呼吸系统疾病（AERD）的特征是嗜酸性鼻窦炎、鼻息肉和支气管哮喘，以及在摄入非甾体抗炎药（NSAIDs）或乙酰水杨酸（ASA）后出现呼吸道反应。除了现有的治疗方案和手术选择外，低饮食摄入食物水杨酸盐已被建议作为这种疾病的辅助治疗。本研究旨在评估短期低水杨酸盐饮食对 AERD 患者炎症标志物的影响，以及这是否会导致症状改善。
前瞻性研究，随机分为高或低水杨酸盐饮食 1 周，然后交叉到另一个研究臂。要求参与者记录研究期间每周的饮食水杨酸盐摄入量。在招募时、第 1 周末和第 2 周末测量尿肌酐、水杨酸盐和白三烯水平，并在同一时间点填写 SNOT-22 问卷。
共有 7 名参与者完成了研究。两种饮食之间的尿水杨酸盐和白三烯水平没有统计学差异；然而，低水杨酸盐饮食组的 SNOT-22 症状评分有所改善（p=0.04），主要在鼻科、耳/面部和睡眠功能障碍症状领域。此外，后两个领域的结果比最小临床重要差异更显著。
短期低水杨酸盐饮食可能不会导致生化结果的改变，但似乎为 AERD 患者提供了显著的症状缓解。
NCT01778465（www.clinicaltrials.gov）。
