Olowosusi O Z, Asoegwu C N, Olagunju A T, Nwawolo C C
Department of Ear, Nose and Throat Surgery, Lagos University Teaching Hospital (LUTH), Lagos, PMB 12003, Nigeria.
Eur Arch Otorhinolaryngol. 2015 Sep;272(9):2341-6. doi: 10.1007/s00405-014-3348-0. Epub 2014 Oct 26.
Quality of Life (QoL) studies are increasingly being used as the primary outcome measure in chronic rhinosinusitis (CRS) globally. However, little is known about QoL and the interplay of identifiable factors on QoL in CRS in sub-Saharan Africa. This study investigated the correlation between disease severity and QoL in chronic rhinosinusitis patients. A total of 147 adults with subjective severity rating of CRS were studied. Participants were assessed using designed questionnaire, Individual Rhinosinusitis Symptom Severity Score Assessment (IRSSSA) and Rhinosinusitis Disability Index (RSDI) questionnaires to elicit socio-demographic/clinical profile, CRS symptom severity and QoL, respectively. The mean age of the participants was 36.86 ± 11.91 years. The mean severity score of all 147 CRS cases was 3.8 ± 1.13. The majority of participants (N = 80; 54.4 %) had moderate disease. The RSDI mean scores for the participants for overall HRQoL were 40.6 ± 19.8. (Median = 40; Range = 77), for physical domain 15.2 ± 7.7, functional domain 12.1 ± 6.4 and emotional domain 13.2 ± 8.2. The trend of association between the disease severity scores and the overall HRQoL on Pearson linear correlation indicates a positive linear association of worsening overall HRQoL with increasing disease severity (R = 0.83; P < 0.0001). The severity of CRS impacted negatively on the HRQoL. All domains were significantly affected by the disease severity particularly the physical domain. Patients adjudged severity of their disease and its' impact on their quality of life should be considered in the determination of the line of their management which could include psychosocial intervention.
生活质量（QoL）研究在全球范围内越来越多地被用作慢性鼻-鼻窦炎（CRS）的主要结局指标。然而，在撒哈拉以南非洲地区，关于CRS患者的生活质量以及可识别因素对生活质量的相互作用知之甚少。本研究调查了慢性鼻-鼻窦炎患者疾病严重程度与生活质量之间的相关性。共研究了147例主观评定CRS严重程度的成年人。使用设计好的问卷、个体鼻-鼻窦炎症状严重程度评分评估（IRSSSA）和鼻-鼻窦炎残疾指数（RSDI）问卷对参与者进行评估，分别以获取社会人口统计学/临床特征、CRS症状严重程度和生活质量。参与者的平均年龄为36.86±11.91岁。147例CRS病例的平均严重程度评分为3.8±1.13。大多数参与者（N = 80；54.4%）患有中度疾病。参与者总体健康相关生活质量的RSDI平均评分为40.6±19.8（中位数 = 40；范围 = 77），身体领域为15.2±7.7，功能领域为12.1±6.4，情感领域为13.2±8.2。Pearson线性相关性分析显示，疾病严重程度评分与总体健康相关生活质量之间的关联趋势表明，随着疾病严重程度增加，总体健康相关生活质量恶化呈正线性关联（R = 0.83；P < 0.0001）。CRS的严重程度对健康相关生活质量有负面影响。所有领域均受到疾病严重程度的显著影响，尤其是身体领域。在确定治疗方案时应考虑患者对自身疾病严重程度及其对生活质量影响的判断，治疗方案可能包括心理社会干预。
