激活与耐受：辅助性T细胞做出的抉择。 - Suppr

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超能文献

Activation versus tolerance: a decision made by T helper cells.

作者信息

Guerder S, Matzinger P

机构信息

Basel Institute of Immunology, Switzerland.

出版信息

Cold Spring Harb Symp Quant Biol. 1989;54 Pt 2:799-805. doi: 10.1101/sqb.1989.054.01.093.

DOI:10.1101/sqb.1989.054.01.093

PMID:2534844

Abstract

摘要

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Activation versus tolerance: a decision made by T helper cells.激活与耐受：辅助性T细胞做出的抉择。

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B cells directly tolerize CD8(+) T cells.B细胞直接使CD8(+) T细胞产生免疫耐受。

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Long-lasting CD8 T cell memory in the absence of CD4 T cells or B cells.在缺乏CD4 T细胞或B细胞的情况下产生持久的CD8 T细胞记忆。

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Thymus epithelium induces tissue-specific tolerance.胸腺上皮诱导组织特异性耐受。

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Induction of long-term H-Y-specific tolerance in female mice given male lymphoid cells while transiently depleted of CD4+ or CD8+ T cells.在雌性小鼠中，当CD4+或CD8+ T细胞暂时耗竭时，给予雄性淋巴细胞可诱导长期的H-Y特异性耐受。

J Exp Med. 1993 Jun 1;177(6):1587-92. doi: 10.1084/jem.177.6.1587.

A quantitative analysis of antigen-presenting cell function: activated B cells stimulate naive CD4 T cells but are inferior to dendritic cells in providing costimulation.抗原呈递细胞功能的定量分析：活化的B细胞刺激初始CD4 T细胞，但在提供共刺激方面不如树突状细胞。

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A fail-safe mechanism for maintaining self-tolerance.一种维持自身耐受性的故障安全机制。

J Exp Med. 1992 Aug 1;176(2):553-64. doi: 10.1084/jem.176.2.553.

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