一种维持自身耐受性的故障安全机制。
A fail-safe mechanism for maintaining self-tolerance.
作者信息
Guerder S, Matzinger P
机构信息
Basel Institute for Immunology, Switzerland.
出版信息
J Exp Med. 1992 Aug 1;176(2):553-64. doi: 10.1084/jem.176.2.553.
Abstract
Using cytotoxic T lymphocyte (CTL) responses to the class I histocompatibility antigen Qa1 and to the minor histocompatibility antigen H-Y, we show that the immune system maintains a peripheral screening process that is able to tolerize a wide variety of potentially autoimmune CTL. The critical factor is the presence or absence of specific T helper cells. If T help is available, CTL precursors that recognize antigen are activated. In the absence of help, they are tolerized. Thus, T helper cells are guardians of peripheral tolerance in CTL.
摘要
利用细胞毒性T淋巴细胞（CTL）对I类组织相容性抗原Qa1和次要组织相容性抗原H-Y的反应，我们发现免疫系统维持着一个外周筛选过程，该过程能够使多种潜在的自身免疫性CTL产生耐受。关键因素是特定T辅助细胞的存在与否。如果有T辅助，识别抗原的CTL前体就会被激活。在没有辅助的情况下，它们会产生耐受。因此，T辅助细胞是CTL外周耐受的守护者。
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Thymic cytotoxic T lymphocytes are primed in vivo to minor histocompatibility antigens.胸腺细胞毒性T淋巴细胞在体内被致敏以识别次要组织相容性抗原。
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