Quinn Elizabeth A, Largado Fe, Borja Judith B, Kuzawa Christopher W
Department of Anthropology, Washington University in St Louis, St Louis, MO, USA
USC-Office of Population Studies Foundation, University of San Carlos, Cebu, Philippines.
J Hum Lact. 2015 May;31(2):273-81. doi: 10.1177/0890334414553247. Epub 2014 Oct 27.
Human milk contains many metabolic hormones that may influence infant growth. Milk leptin is positively associated with maternal adiposity and inversely associated with infant growth. Most research has been conducted in populations with higher leptin levels; it is not well understood how milk leptin may vary in lean populations or the associations that reduced leptin may have with infant size for age. It is also largely unknown if associations between maternal body composition and milk leptin persist past 1 year of age.
We investigated the association between maternal body composition and milk leptin content in a sample of lean Filipino women and the association between milk leptin content and infant size for age.
Milk samples were collected at in-home visits from 113 mothers from Cebu, Philippines. Milk leptin content was measured using EIA techniques; anthropometric data, dietary recalls, and household information were also collected.
Mean ± standard deviation (SD) milk leptin in this sample was 300.7 ± 293.6 pg/mL, among the lowest previously reported. Mean ± SD maternal percentage body fat was 24.8% ± 3.5%. Mean ± SD infant age was 9.9 ± 7.0 months, and mean ± SD weight for age z-score was -0.98 ± 1.06. Maternal percentage body fat was a significant, positive predictor of milk leptin content. Milk leptin was a significant, inverse predictor of infant weight and body mass index z-scores in infants 1 year old or younger.
The association between maternal body composition, milk leptin, and infant growth persists in mothers with lean body composition. Milk leptin is not associated with growth in older infants.
人乳中含有许多可能影响婴儿生长的代谢激素。乳瘦素与母亲肥胖呈正相关，与婴儿生长呈负相关。大多数研究是在瘦素水平较高的人群中进行的；目前尚不清楚在瘦人群体中乳瘦素如何变化，以及较低的瘦素与婴儿年龄别大小之间的关联。母亲身体成分与乳瘦素之间的关联在1岁以后是否持续也很大程度上未知。
我们在一组瘦的菲律宾女性样本中研究了母亲身体成分与乳瘦素含量之间的关联，以及乳瘦素含量与婴儿年龄别大小之间的关联。
在菲律宾宿务对113名母亲进行家访时收集乳汁样本。使用酶免疫分析技术测量乳瘦素含量；还收集了人体测量数据、饮食回忆和家庭信息。
该样本中乳瘦素的平均值±标准差（SD）为300.7±293.6 pg/mL，是此前报道的最低值之一。母亲体脂百分比的平均值±标准差为24.8%±3.5%。婴儿平均年龄±标准差为9.9±7.0个月，年龄别体重z评分的平均值±标准差为-0.98±1.06。母亲体脂百分比是乳瘦素含量的显著正预测因子。乳瘦素是1岁及以下婴儿体重和体重指数z评分的显著负预测因子。
母亲身体成分、乳瘦素与婴儿生长之间的关联在身体瘦的母亲中持续存在。乳瘦素与较大婴儿的生长无关。
