Departamento de Química y Bioquímica, Facultad de Farmacia, Universidad CEU San Pablo, Urbanización Monteprincipe, 28668 Madrid, Spain.
Org Biomol Chem. 2015 Jan 7;13(1):142-56. doi: 10.1039/c4ob01516a.
MMP-2 is a validated target for the development of anticancer agents. Herein we describe the synthesis of a new series of potent phenylalanine derived hydroxamates, with increased MMP-2/MMP-9 selectivity compared to analogous hydroxamates described previously. Docking and molecular dynamics experiments have been used to account for this selectivity, and to clarify the role of the triazole ring in the binding process.
MMP-2 是抗癌药物开发的一个经过验证的靶点。本文描述了一系列新型强效苯丙氨酸衍生的羟肟酸的合成，与以前描述的类似羟肟酸相比，对 MMP-2/MMP-9 的选择性更高。对接和分子动力学实验用于解释这种选择性，并阐明三唑环在结合过程中的作用。
