Kang K Y, Kwok S-K, Ju J H, Park K-S, Park S-H, Hong Y S
Division of Rheumatology, Department of Internal Medicine, Incheon St Mary's Hospital, The Catholic University of Korea , Incheon , South Korea.
Scand J Rheumatol. 2015;44(2):125-8. doi: 10.3109/03009742.2014.938693. Epub 2014 Oct 29.
The formation of spinal syndesmophytes is an important outcome measure in ankylosing spondylitis (AS) but the predictors of new syndesmophyte development in female AS patients are unknown. This longitudinal study aimed to assess the rate and predictors of development of new syndesmophytes over a 2-year period in female AS patients.
Clinical and radiographic data were collected at baseline and after 2 years in 67 female AS patients. Spinal radiographs were scored using the Stoke AS Spinal Score (SASSS). Univariate logistic regression analyses were performed to identify predictors associated with new syndesmophyte development.
Eleven (16%) patients had syndesmophytes at baseline. Nine (13.4%) patients had developed new syndesmophytes in their lumbar spines after 2 years. In the univariate logistic regression analyses, older age, longer disease duration, severe sacroiliitis, elevated C-reactive protein (CRP) levels at baseline, and one or more pre-existing syndesmophytes were associated with the occurrence of new syndesmophytes. After adjustment for baseline SASSS, increases in SASSS were statistically significantly higher in patients with elevated baseline CRP levels (p = 0.002) than in patients with normal CRP at baseline.
Older age, longer disease duration, severe sacroiliitis, the baseline presence of syndesmophytes, and elevated levels of CRP are predictors of the development of new syndesmophytes in female AS patients.
脊柱骨桥形成是强直性脊柱炎（AS）的一项重要结局指标，但女性AS患者新骨桥形成的预测因素尚不清楚。这项纵向研究旨在评估女性AS患者在2年期间新骨桥形成的发生率及预测因素。
收集了67例女性AS患者基线时及2年后的临床和影像学数据。使用斯托克强直性脊柱炎脊柱评分（SASSS）对脊柱X线片进行评分。进行单因素逻辑回归分析以确定与新骨桥形成相关的预测因素。
11例（16%）患者在基线时存在骨桥。9例（13.4%）患者在2年后腰椎出现了新骨桥。在单因素逻辑回归分析中，年龄较大、病程较长、重度骶髂关节炎、基线时C反应蛋白（CRP）水平升高以及一个或多个既往存在的骨桥与新骨桥的发生相关。在对基线SASSS进行校正后，基线CRP水平升高的患者SASSS的增加在统计学上显著高于基线CRP正常的患者（p = 0.002）。
年龄较大、病程较长、重度骶髂关节炎、基线时存在骨桥以及CRP水平升高是女性AS患者新骨桥形成的预测因素。
