Günther T, Vormann J, Höllriegl V
Institut für Molekularbiologie und Biochemie, Freie Universität Berlin, Fed. Rep. of Germany.
J Trace Elem Electrolytes Health Dis. 1989 Sep;3(3):161-4.
Pregnant and non pregnant rats were fed diets with different Mg content and treated with 5 oral doses of 300 mg/kg salicylic acid for 5 consecutive days or from day 16 to 20 of gestation. One day after the final dosage, serum Mg and Ca concentrations were measured by atomic absorption spectrophotometry. In maternal rats, salicylate caused a strong decrease of serum Ca with increasing serum Mg concentrations (r = -0.8706). In fetal and nonpregnant adult female rats, serum Ca was not significantly decreased by salicylate with increasing serum Mg concentrations. However, the hypocalcemic effect of salicylate was found when nonpregnant young growing rats were fed a Ca-deficient diet.
给怀孕和未怀孕的大鼠喂食镁含量不同的日粮，连续5天或在妊娠第16至20天口服5剂300mg/kg水杨酸。末次给药后一天，用原子吸收分光光度法测定血清镁和钙浓度。在母鼠中，随着血清镁浓度升高，水杨酸盐导致血清钙显著降低（r=-0.8706）。在胎鼠和未怀孕的成年雌性大鼠中，随着血清镁浓度升高，水杨酸盐不会显著降低血清钙。然而，当给未怀孕的幼年生长大鼠喂食缺钙日粮时，发现了水杨酸盐的低钙血症效应。
