Ifon E T, Ifere G O, Ebong P E, Umoh I B, Nwangwa M
Department of Biochemistry, College of Medical Sciences, University of Calabar, Nigeria.
J Trace Elem Electrolytes Health Dis. 1989 Dec;3(4):199-201.
During iron deficiency a significant (p less than 0.01) increase in erythrocyte Na+ in vivo was observed in both rats and humans. Erythrocyte K+ was down, but the effect was only significant (p less than 0.05) in rats, under this condition. However, erythrocyte Na+/K+ ratio was significantly (p less than 0.001) higher in iron deficiency when compared to normal values in both rats and humans. Although there was no significant (p greater than 0.05) correlation between Haemoglobin (Hb), Packed cell volume (PCV), Plasma Fe, and Total Iron Binding capacity (TIBC), and erythrocyte Na+ or K+ levels during iron deficiency, analysis of variance showed that Hb, PCV, Plasma Fe and TIBC in concert significantly (p less than 0.05) affected erythrocyte Na+ in iron-deficient rats and humans, whereas K+ was significantly (p less than 0.05) affected only in rats. These studies suggest a defect in erythrocyte membrane function during iron deficiency and imply a concerted potentiating effect of Hb, PCV, Plasma Fe and TIBC on erythrocyte membrane malfunction during iron deficiency. Species difference is also demonstrated in erythrocyte (Na+ and K+) translocation in iron deficiency.
在缺铁状态下，大鼠和人类体内红细胞的钠离子均显著增加（p < 0.01）。红细胞的钾离子减少，但仅在大鼠中，这种影响具有统计学意义（p < 0.05）。然而，与正常水平相比，缺铁状态下大鼠和人类的红细胞钠钾比均显著升高（p < 0.001）。尽管缺铁期间血红蛋白（Hb）、红细胞压积（PCV）、血浆铁和总铁结合力（TIBC）与红细胞钠或钾水平之间无显著相关性（p > 0.05），但方差分析显示，缺铁大鼠和人类中，Hb、PCV、血浆铁和TIBC共同对红细胞钠有显著影响（p < 0.05），而钾离子仅在大鼠中受到显著影响（p < 0.05）。这些研究表明缺铁期间红细胞膜功能存在缺陷，并提示Hb、PCV、血浆铁和TIBC在缺铁期间对红细胞膜功能障碍有协同增强作用。缺铁时红细胞（钠和钾）转运的种属差异也得到了证实。
