一种高效的试剂，可将炔烃共价引入蛋白质中。
An efficient reagent for covalent introduction of alkynes into proteins.
机构信息
State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, 15 Beisanhuan East Road, Chaoyang District, Beijing 100029, China.
出版信息
Org Biomol Chem. 2014 Dec 21;12(47):9528-31. doi: 10.1039/c4ob01873g. Epub 2014 Oct 30.
PMID:25354584
Abstract
A cheap and bench-stable reagent was synthesized for direct and covalent introduction of alkynes into tyrosine of target proteins, which can be further modified based on click reaction to achieve fluorescence labelling or PEGylation. This reagent should be a generally useful toolbox for chemical biology and biomaterials.
摘要
一种廉价且在实验台上稳定的试剂被合成出来，用于直接和共价地将炔烃引入靶蛋白中的酪氨酸，然后可以进一步根据点击反应进行修饰，以实现荧光标记或聚乙二醇化。该试剂应该成为化学生物学和生物材料领域一个非常有用的工具包。
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