通过快原子轰击质谱法和1H-/13C-核磁共振光谱法相结合确定人乳九糖和十糖的一级结构。一种新核心结构——异乳糖-N-八糖的证据。
Primary structure of human milk nona- and decasaccharides determined by a combination of fast atom bombardment mass spectrometry and 1H-/13C-nuclear magnetic resonance spectroscopy. Evidence for a new core structure, iso-lacto-N-octaose.
作者信息
Strecker G, Wieruszeski J M, Michalski J C, Montreuil J
机构信息
Laboratoire de Chimie Biologique, Université des Sciences et Techniques de Lille Flandres-Artois, Villeneuve d'Ascq, France.
出版信息
Glycoconj J. 1989;6(2):169-82. doi: 10.1007/BF01050646.
The structure of a nonasaccharide and of two decasaccharides isolated from human milk has been investigated by using methylation, fast atom bombardment mass spectrometry and 1H-/13C-nuclear magnetic resonance spectroscopy. The structures of these oligosaccharides were: trifucosyllacto-N-hexaose; Fuc alpha 1-2Gal beta 1-3(Fuc alpha 1-4)GlcNAc beta 1-3[Gal beta 1-4(Fuc alpha 1-3)GlcNAc beta 1-6]Gal beta 1-4Glc, difucosyllacto-N-octaoses; Gal beta 1-3(Fuc alpha 1-4)GlcNAc beta 1-3Gal beta 1-4(Fuc alpha 1-3)GlcNAc beta 1-6[Gal beta 1-3GlcNAc beta 1-3]Gal beta 1-4Glc and Gal beta 1-3GlcNAc beta 1-3Gal beta 1-4(Fuc alpha 1-3)GlcNAc beta 1-6[Fuc alpha 1-3 Gal beta 1-3GlcNAc beta 1-3]Gal beta 1-4Glc. The two decasaccharides possess a new type of core structure proposed to be named iso-lacto-N-octaose.
通过甲基化、快原子轰击质谱法和1H-/13C-核磁共振光谱法，对从人乳中分离出的一种九糖和两种十糖的结构进行了研究。这些寡糖的结构如下：三岩藻糖基乳糖-N-六糖；Fucα1-2Galβ1-3（Fucα1-4）GlcNAcβ1-3[Galβ1-4（Fucα1-3）GlcNAcβ1-6]Galβ1-4Glc，二岩藻糖基乳糖-N-八糖；Galβ1-3（Fucα1-4）GlcNAcβ1-3Galβ1-4（Fucα1-3）GlcNAcβ1-6[Galβ1-3GlcNAcβ1-3]Galβ1-4Glc和Galβ1-3GlcNAcβ1-3Galβ1-4（Fucα1-3）GlcNAcβ1-6[Fucα1-3Galβ1-3GlcNAcβ1-3]Galβ1-4Glc。这两种十糖具有一种新型的核心结构，建议将其命名为异乳糖-N-八糖。
Zotero 插件