Sato Shingo, Takeda Shu
Department of Physiology and Cell Biology, Tokyo Medical and Dental University Graduate School and Faculty of Medicine, Japan.
Clin Calcium. 2014 Nov;24(11):1591-8.
Lifestyle-related diseases such as diabetes mellitus, chronic kidney disease, and hypertension were previously considered to be unrelated to osteoporosis. However, recent investigations have demonstrated that lifestyle-related diseases have a significant effect on the regulation of bone metabolism. In addition, it has been also revealed that osteocalcin or fibroblast growth factor 23 (FGF23) , which is produced by osteoblasts, has an important role in glucose metabolism, fat metabolism, or calcium homeostasis. These findings suggest that bone is not only a target organ of hormones but also involved in regulating other organs as an endocrine organ. This review introduces such a bidirectional relationship between several lifestyle-related diseases and bone metabolism.
糖尿病、慢性肾脏病和高血压等生活方式相关疾病以前被认为与骨质疏松症无关。然而，最近的研究表明，生活方式相关疾病对骨代谢调节有显著影响。此外，还发现成骨细胞产生的骨钙素或成纤维细胞生长因子23（FGF23）在葡萄糖代谢、脂肪代谢或钙稳态中起重要作用。这些发现表明，骨骼不仅是激素的靶器官，还作为内分泌器官参与调节其他器官。本文综述介绍了几种生活方式相关疾病与骨代谢之间的这种双向关系。
