Kanazawa Ippei, Sugimoto Toshitsugu
Internal Medicine 1, Shimane University Faculty of Medicine, Japan.
Clin Calcium. 2016 Mar;26(3):399-404.
Accumulating evidence shows that life-style related diseases such as diabetes mellitus, hypertension, dyslipidemia are associated with bone and calcium metabolism. Patients with diabetes mellitus have increased fracture risks, independently of bone mineral density, with abnormality of parathyroid hormone secretion and impaired osteoblastic function. On the other hand, osteocalcin secreted from bone is reported to regulate glucose metabolism. Thus, bone, calcium and glucose metabolism may be deeply associated with each other. In this review, we describe the association between life-style related diseases, especially diabetes mellitus, and metabolism of bone and calcium.
越来越多的证据表明，糖尿病、高血压、血脂异常等生活方式相关疾病与骨骼和钙代谢有关。糖尿病患者骨折风险增加，与骨矿物质密度无关，伴有甲状旁腺激素分泌异常和成骨细胞功能受损。另一方面，据报道，骨骼分泌的骨钙素可调节葡萄糖代谢。因此，骨骼、钙和葡萄糖代谢可能彼此密切相关。在这篇综述中，我们描述了生活方式相关疾病，尤其是糖尿病，与骨骼和钙代谢之间的关联。
