El Mays Tamer Y, Choudhury Parichita, Leigh Richard, Koumoundouros Emmanuel, Van der Velden Joanne, Shrestha Grishma, Pieron Cora A, Dennis John H, Green Francis Hy, Snibson Ken J
Respir Res. 2014 Sep 16;15(1):98. doi: 10.1186/s12931-014-0098-x.
The low toxicity of perfluorocarbons (PFCs), their high affinity for respiratory gases and their compatibility with lung surfactant have made them useful candidates for treating respiratory diseases such as adult respiratory distress syndrome. We report results for treating acute allergic and non-allergic bronchoconstriction in sheep using S-1226 (a gas mixture containing carbon dioxide and small volumes of nebulized perflubron). The carbon dioxide, which is highly soluble in perflubron, was used to relax airway smooth muscle.
Sheep previously sensitized to house dust mite (HDM) were challenged with HDM aerosols to induce early asthmatic responses. At the maximal responses (characterised by an increase in lung resistance), the sheep were either not treated or treated with one of the following; nebulized S-1226 (perflubron + 12% CO2), nebulized perflubron + medical air, 12% CO2, salbutamol or medical air. Lung resistance was monitored for up to 20 minutes after cessation of treatment.
Treatment with S-1226 for 2 minutes following HDM challenge resulted in a more rapid, more profound and more prolonged decline in lung resistance compared with the other treatment interventions. Video bronchoscopy showed an immediate and complete (within 5 seconds) re-opening of MCh-constricted airways following treatment with S-1226.
S-1226 is a potent and rapid formulation for re-opening constricted airways. Its mechanism(s) of action are unknown. The formulation has potential as a rescue treatment for acute severe asthma.
全氟化碳（PFCs）毒性低、对呼吸气体亲和力高且与肺表面活性剂具有相容性，使其成为治疗诸如成人呼吸窘迫综合征等呼吸系统疾病的理想候选物质。我们报告了使用S - 1226（一种含有二氧化碳和少量雾化全氟溴辛烷的气体混合物）治疗绵羊急性过敏性和非过敏性支气管收缩的结果。高度溶于全氟溴辛烷的二氧化碳用于舒张气道平滑肌。
预先对屋尘螨（HDM）致敏的绵羊用HDM气雾剂激发以诱导早期哮喘反应。在出现最大反应（以肺阻力增加为特征）时，对绵羊不进行治疗或采用以下其中一种方法进行治疗；雾化S - 1226（全氟溴辛烷 + 12%二氧化碳）、雾化全氟溴辛烷 + 医用空气、12%二氧化碳、沙丁胺醇或医用空气。治疗停止后监测肺阻力长达20分钟。
与其他治疗干预措施相比，HDM激发后用S - 1226治疗2分钟导致肺阻力下降更快、更显著且更持久。视频支气管镜检查显示，用S - 1226治疗后，MCh收缩的气道立即（5秒内）完全重新开放。
S - 1226是一种强效且快速的使收缩气道重新开放的制剂。其作用机制尚不清楚。该制剂有潜力作为急性重度哮喘的抢救治疗药物。
