El-Betany Alaa M M, Behiry Enas M, Gumbleton Mark, Harding Keith G
School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, United Kingdom.
School of Medicine, Institute of Infection and Immunity, Cardiff University, Cardiff, United Kingdom.
Front Med (Lausanne). 2020 Dec 11;7:594295. doi: 10.3389/fmed.2020.594295. eCollection 2020.
The coronavirus disease (COVID-19) outbreak has presented enormous challenges for healthcare, societal, and economic systems worldwide. There is an urgent global need for a universal vaccine to cover all SARS-CoV-2 mutant strains to stop the current COVID-19 pandemic and the threat of an inevitable second wave of coronavirus. Carbon dioxide is safe and superior antimicrobial, which suggests it should be effective against coronaviruses and mutants thereof. Depending on the therapeutic regime, CO could also ameliorate other COVID-19 symptoms as it has also been reported to have antioxidant, anti-inflammation, anti-cytokine effects, and to stimulate the human immune system. Moreover, CO has beneficial effects on respiratory physiology, cardiovascular health, and human nervous systems. This article reviews the rationale of early treatment by inhaling safe doses of warmed humidified CO gas, either alone or as a carrier gas to deliver other inhaled drugs may help save lives by suppressing SARS-CoV-2 infections and excessive inflammatory responses. We suggest testing this somewhat counter-intuitive, but low tech and safe intervention for its suitability as a preventive measure and treatment against COVID-19. Overall, development and evaluation of this therapy now may provide a safe and economical tool for use not only during the current pandemic but also for any future outbreaks of respiratory diseases and related conditions.
冠状病毒病(COVID-19)疫情给全球的医疗、社会和经济系统带来了巨大挑战。全球迫切需要一种通用疫苗来覆盖所有严重急性呼吸综合征冠状病毒2(SARS-CoV-2)突变株,以阻止当前的COVID-19大流行以及不可避免的第二波冠状病毒威胁。二氧化碳是一种安全且高效的抗菌剂,这表明它应该对冠状病毒及其突变体有效。根据治疗方案,一氧化碳还可以改善其他COVID-19症状,因为据报道它还具有抗氧化、抗炎、抗细胞因子作用,并能刺激人体免疫系统。此外,一氧化碳对呼吸生理、心血管健康和人类神经系统有有益影响。本文综述了早期吸入安全剂量的温热加湿一氧化碳气体进行治疗的基本原理,单独使用或作为输送其他吸入药物的载气,可能通过抑制SARS-CoV-2感染和过度炎症反应来挽救生命。我们建议测试这种有些违反直觉但技术含量低且安全的干预措施,看其是否适合作为预防和治疗COVID-19的方法。总体而言,现在开发和评估这种疗法可能会提供一种安全且经济的工具,不仅可用于当前的大流行期间,也可用于未来任何呼吸系统疾病及相关病症的爆发。