前列腺素E2增强白细胞三烯C4抑制白细胞介素-1对WEHI-3B细胞生长的抑制作用。
Prostaglandin E2 enhances, and leukotriene C4 inhibits, interleukin-1 inhibition of WEHI-3B cell growth.
作者信息
Elliott G R, Tak C, Bonta I L
机构信息
Department of Pharmacology, Medical Faculty, Erasmus University Rotterdam, The Netherlands.
出版信息
Cancer Immunol Immunother. 1989;28(1):74-6. doi: 10.1007/BF00205804.
Abstract
Human recombinant interleukin-1 (HrIL-1) inhibited WEHI-3B cell growth in a dose-related manner (10-10,000 U/ml). Prostaglandin E2 at high concentrations (1000 ng/ml) also inhibited cell growth. When added together, HrIL-1 and prostaglandin E2 inhibited WEHI-3B growth in a synergistic manner (HrIL-1 concentrations of 10-10,000 U/ml and prostaglandin E2 concentrations of 10-1000 ng/ml). In contrast to the effects of the cyclooxygenase metabolite of arachidonic acid leukotriene C4, a lipoxygenase metabolite, reversed the cytostatic action of HrIL-1.
摘要
人重组白细胞介素-1（HrIL-1）以剂量相关方式（10 - 10000 U/ml）抑制WEHI-3B细胞生长。高浓度（1000 ng/ml）的前列腺素E2也抑制细胞生长。当两者一起添加时，HrIL-1和前列腺素E2以协同方式抑制WEHI-3B生长（HrIL-1浓度为10 - 10000 U/ml，前列腺素E2浓度为10 - 1000 ng/ml）。与花生四烯酸的环氧化酶代谢产物的作用相反，脂氧合酶代谢产物白三烯C4逆转了HrIL-1的细胞生长抑制作用。
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