Roszkowska Renata, Taranta-Janusz Katarzyna, Tenderenda-Banasiuk Edyta, Wasilewska Anna
Department of Pediatrics and Nephrology, Medical University of Białystok , Białystok, Poland .
Breastfeed Med. 2015 Jan-Feb;10(1):38-44. doi: 10.1089/bfm.2014.0128. Epub 2014 Oct 30.
The purpose of this work was to investigate the association of serum asymmetric dimethylarginine (ADMA) and high-sensitivity C-reactive protein (hs-CRP) levels with duration of breastfeeding and body composition in children.
The study group consisted of 88 patients with a median age of 12 months (42 boys, 46 girls), classified as never breastfed or fully breastfed. ADMA and hs-CRP were measured by immunoenzymatic enzyme-linked immunosorbent assay commercial kits. Body composition analysis was performed by bioelectrical impedance.
We found significantly higher serum ADMA levels but not serum hs-CRP levels in never breastfed compared with the fully breastfed group (p<0.05). Serum ADMA was inversely associated with high-density lipoprotein-cholesterol levels and breastfeeding duration (p<0.05). Positive correlation was found between ADMA and body fat mass (p<0.05).
In never breastfed children, increased ADMA is observed; however, further studies are needed to assess whether breastfeeding duration affects body fat and body composition at older ages.
本研究旨在探讨儿童血清不对称二甲基精氨酸（ADMA）和高敏C反应蛋白（hs-CRP）水平与母乳喂养持续时间及身体成分之间的关联。
研究组由88名年龄中位数为12个月的患者组成（42名男孩，46名女孩），分为从未母乳喂养或完全母乳喂养组。采用免疫酶联免疫吸附测定商业试剂盒检测ADMA和hs-CRP。通过生物电阻抗法进行身体成分分析。
我们发现，与完全母乳喂养组相比，从未母乳喂养组的血清ADMA水平显著更高，但血清hs-CRP水平无显著差异（p<0.05）。血清ADMA与高密度脂蛋白胆固醇水平及母乳喂养持续时间呈负相关（p<0.05）。ADMA与体脂量呈正相关（p<0.05）。
在从未母乳喂养的儿童中观察到ADMA升高；然而，需要进一步研究以评估母乳喂养持续时间是否会影响大龄儿童的体脂和身体成分。
