在野百合碱诱导的肺动脉高压大鼠中，拉伸对小梁张力和Ca(2+)瞬变的依赖性效应中的性别差异。
Sex differences in stretch-dependent effects on tension and Ca(2+) transient of rat trabeculae in monocrotaline pulmonary hypertension.
作者信息
Lookin Oleg, Kuznetsov Daniil, Protsenko Yuri
机构信息
Laboratory of Biological Motility, Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, Yekaterinburg, 620049, Russia,
出版信息
J Physiol Sci. 2015 Jan;65(1):89-98. doi: 10.1007/s12576-014-0341-8. Epub 2014 Oct 31.
We aim to compare the effects of stretch on isometric tension/Ca(2+) transient in the right ventricular trabeculae of control (CONT) and hypertensive (MCT, monocrotaline application) adult male and female rats. The treatment with MCT resulted in RV hypertrophy in males only. Blunted active force-length relation and substantially prolonged twitch were found in MCT-males but not MCT-females (vs same-sex CONT). Ca(2+) transient was prolonged in both MCT-treated groups but extremely so in the MCT-males. The gradual stretch resulted in a distinct "bump" on Ca(2+) transient decline in CONT and MCT-treated groups. The integral magnitude of the "bump" was unaffected by the treatment with MCT in males or females but was larger in males vs females. The rate of "bump" development was significantly slower in MCT-males. In conclusion, the sex-specific differences in the stretch-dependent regulation of [Ca(2+)] i may underlie preservation of the Frank-Starling mechanism in female rat myocardium in monocrotaline-induced pulmonary hypertension.
我们旨在比较拉伸对成年雄性和雌性对照（CONT）大鼠及高血压（MCT，应用野百合碱）大鼠右心室小梁等长张力/Ca(2+)瞬变的影响。MCT处理仅导致雄性大鼠右心室肥大。在MCT雄性大鼠中发现主动力-长度关系钝化且抽搐明显延长，但MCT雌性大鼠未出现（与同性CONT组相比）。两个MCT处理组的Ca(2+)瞬变均延长，但MCT雄性大鼠尤为明显。逐渐拉伸导致CONT组和MCT处理组的Ca(2+)瞬变下降出现明显的“隆起”。“隆起”的积分幅度不受MCT处理的影响，在雄性和雌性中均如此，但雄性大于雌性。MCT雄性大鼠中“隆起”的发展速率明显较慢。总之，在野百合碱诱导的肺动脉高压中，雌性大鼠心肌中[Ca(2+)]i拉伸依赖性调节的性别特异性差异可能是Frank-Starling机制得以保留的基础。
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