Nagasue N, Kohno H, Chang Y C, Hayashi T, Utsumi Y, Nakamura T, Yukaya H
Second Department of Surgery, Shimane Medical University, Izumo, Japan.
Cancer. 1989 Jan 1;63(1):112-6. doi: 10.1002/1097-0142(19890101)63:1<112::aid-cncr2820630118>3.0.co;2-p.
Androgen receptors (AR) and estrogen receptors (ER) were consecutively assayed for hepatocellular carcinoma (HCC) and the surrounding liver was removed surgically from 19 female patients. Patient age ranged from 43 to 79 years, with an average of 61 +/- 9 years. All patients had underlying liver disease (liver cirrhosis in 16, liver fibrosis in two, and chronic hepatitis in one). Seven (37%) of 19 HCC had AR ranging from 2.3 to 82.6 fmol/mg of cytosol protein. The AR titer was higher in the HCC than in the liver in these cases. Three cases also had ER. ER existed in seven (37%) tumors (range, 2.4 to 25.6 fmol/mg of protein). AR and ER were detected in 11 (65%) and ten (58%) of 17 nonneoplastic liver tissues, respectively. Serum alpha-fetoprotein (AFP) level, hepatitis B virus markers, or histopathologic types of HCC had no correlation with the presence or absence of AR or ER and their titers. Also, there was no correlation between the AR and ER positivities. Further studies are mandatory to determine the genuine role of sex hormone receptors in the development and growth of HCC in humans.
对19例女性肝细胞癌（HCC）患者连续检测雄激素受体（AR）和雌激素受体（ER），并手术切除其周围肝脏组织。患者年龄范围为43至79岁，平均年龄为61±9岁。所有患者均有基础肝病（16例为肝硬化，2例为肝纤维化，1例为慢性肝炎）。19例HCC中有7例（37%）的AR水平为2.3至82.6 fmol/mg胞浆蛋白。在这些病例中，HCC的AR滴度高于肝脏。3例还检测到ER。7例（37%）肿瘤存在ER（范围为2.4至25.6 fmol/mg蛋白）。在17例非肿瘤性肝组织中，分别有11例（65%）和10例（58%）检测到AR和ER。血清甲胎蛋白（AFP）水平、乙肝病毒标志物或HCC的组织病理学类型与AR或ER的有无及其滴度均无相关性。此外，AR和ER阳性之间也无相关性。必须进行进一步研究以确定性激素受体在人类HCC发生和发展中的真正作用。
