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肛周佩吉特病

Perianal Paget's Disease.

作者信息

Kim Chang Woo, Kim Yon Hee, Cho Min Soo, Min Byung Soh, Baik Seung Hyuk, Kim Nam Kyu

机构信息

Division of Colon and Rectal Surgery, Department of Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

出版信息

Ann Coloproctol. 2014 Oct;30(5):241-4. doi: 10.3393/ac.2014.30.5.241. Epub 2014 Oct 28.

DOI:10.3393/ac.2014.30.5.241
PMID:25360433
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4213942/
Abstract

The incidence of extramammary Paget's disease (EMPD) is very low. An 84-year-old Korean man was treated with topical and oral medications at a local dermatologic clinic for a year, but the symptoms did not improve. He visited Severance Hospital and underwent a perianal skin biopsy and was finally diagnosed with EMPD. The authors performed a wide local excision according to a 1-cm margin around the lesion. For the skin and the soft tissue defects, bilateral inferior gluteal artery perforator flap transpositions were performed. The size of the lesion was 14 cm(2) × 9 cm(2), and the lateral and the basal margins were all disease free.

摘要

乳腺外佩吉特病(EMPD)的发病率非常低。一名84岁的韩国男性在当地皮肤科诊所接受了一年的局部和口服药物治疗,但症状并未改善。他前往Severance医院,接受了肛周皮肤活检,最终被诊断为EMPD。作者在病变周围1厘米边缘处进行了广泛的局部切除。对于皮肤和软组织缺损,进行了双侧臀下动脉穿支皮瓣转移术。病变大小为14平方厘米×9平方厘米,外侧和基底边缘均无病变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2548/4213942/2bcd7402b7c9/ac-30-241-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2548/4213942/6cd26902cbae/ac-30-241-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2548/4213942/2bcd7402b7c9/ac-30-241-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2548/4213942/6cd26902cbae/ac-30-241-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2548/4213942/2bcd7402b7c9/ac-30-241-g002.jpg

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本文引用的文献

1
Immunohistochemical and fluorescence in situ hybridization studies on noninvasive and invasive extramammary Paget's disease.非侵袭性和侵袭性乳腺外佩吉特病的免疫组织化学及荧光原位杂交研究
Int J Surg Pathol. 2012 Oct;20(5):441-8. doi: 10.1177/1066896912444159.
2
A multicenter study on extramammary Paget's disease in Korea.一项针对韩国派杰氏病的多中心研究。
Int J Dermatol. 2011 May;50(5):508-15. doi: 10.1111/j.1365-4632.2010.04661.x.
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Extra-mammary Paget's disease of the perianal region: a review of the literature emphasizing the operative management technique.
Int J Surg Case Rep. 2016;24:153-5. doi: 10.1016/j.ijscr.2016.05.044. Epub 2016 Jun 3.
肛门周围区域的乳房外帕哲病:文献复习强调手术治疗方法。
Surg Oncol. 2011 Jun;20(2):e61-71. doi: 10.1016/j.suronc.2010.09.005.
4
Immunohistochemical study of HER2 and TUBB3 proteins in extramammary Paget disease.乳腺外佩吉特病中HER2和TUBB3蛋白的免疫组织化学研究
Am J Dermatopathol. 2010 Aug;32(6):578-85. doi: 10.1097/DAD.0b013e3181cd35e0.
5
Mammary and extramammary Paget's disease.乳腺及乳腺外佩吉特病。
J Eur Acad Dermatol Venereol. 2007 May;21(5):581-90. doi: 10.1111/j.1468-3083.2007.02154.x.
6
Treatment of extramammary Paget disease with topical imiquimod cream: case report and literature review.外用咪喹莫特乳膏治疗乳房外佩吉特病:病例报告及文献复习
South Med J. 2006 Apr;99(4):396-402. doi: 10.1097/01.smj.0000209223.68763.b1.
7
Extramammary Paget's disease of the genitalia with clinically clear margins can be adequately resected with 1 cm margin.具有临床清晰切缘的生殖器外佩吉特病可采用1厘米切缘进行充分切除。
Eur J Dermatol. 2005 May-Jun;15(3):168-70.
8
Extramammary Paget's disease: role of radiation therapy.乳房外佩吉特病:放射治疗的作用
Australas Radiol. 2002 Jun;46(2):204-8. doi: 10.1046/j.1440-1673.2001.01039.x.
9
Classic articles in colonic and rectal surgery: Sir James Paget, 1814-1899, on disease of the mammary areola preceeding cancer of the mammary gland.结肠和直肠手术的经典文章:詹姆斯·佩吉特爵士,1814 - 1899年,论乳腺乳晕疾病先于乳腺癌。
Dis Colon Rectum. 1980 May-Jun;23(4):280-1.
10
[Intralesional interferon in the treatment of extramammary Paget's disease].[瘤内注射干扰素治疗乳房外佩吉特病]
Nihon Hifuka Gakkai Zasshi. 1987 Jan;97(1):1-7.