Xiong Xing-Jiang, Wang Zhong, Wang Jie
Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beixiange 5#, Xicheng District, Beijing 100053, China.
Curr Vasc Pharmacol. 2015;13(4):540-53. doi: 10.2174/1570161112666141014153735.
Coronary heart disease (CHD) is one of the leading causes of death worldwide. Moreover, angina pectoris is one of the most important types of CHD. Therefore, prevention and effective treatment of angina pectoris is of utmost importance in both China and western countries. However, undesirable effects of antianginal therapy do influence treatment adherence to a certain extent. Therefore, it's not surprising that, complementary and alternative medicine (CAM), including Chinese medicine (CM), are widely welcomed among patients with CHD, hoping that it might complement western medicine. In our previous studies, blood stasis syndrome (BSS) (Xueyu Zheng) was the main syndrome (Zheng-hou) of angina pectoris. Currently, China Food and Drug Administration authoritatively recommended more than 200 Chinese patent medicines (CPMs) as complementary or adjunctive therapies for symptom management and enhancing quality of life along with mainstream care on angina pectoris management in mainland China. This paper reviewed 4 kinds of most frequently-used CPMs by promoting blood circulation and removing blood stasis in the treatment of angina pectoris. It aims to evaluate the current evidence of CPMs in combination therapy for angina pectoris. This review indicated that CPMs as adjunctive treatment to routine antianginal therapy play an active role in reducing the incidence of primary endpoint events, decreasing anginal attack rate, and improving electrocardiogram. Additionally, CPMs have been proven relatively safe. Further rigorously designed clinical trials should be conducted to confirm the results.
冠心病(CHD)是全球主要死因之一。此外,心绞痛是冠心病最重要的类型之一。因此,在中国和西方国家,预防和有效治疗心绞痛都至关重要。然而,抗心绞痛治疗的不良影响在一定程度上确实会影响治疗依从性。因此,包括中药(CM)在内的补充和替代医学(CAM)在冠心病患者中受到广泛欢迎也就不足为奇了,患者希望它能补充西药。在我们之前的研究中,血瘀证(BSS)(血瘀证)是心绞痛的主要证候(证候)。目前,中国国家食品药品监督管理总局权威推荐200多种中成药(CPMs)作为中国大陆心绞痛管理中症状管理和提高生活质量的补充或辅助疗法,与主流治疗方法并用。本文综述了4种最常用的通过活血化瘀治疗心绞痛的中成药。旨在评估中成药在心绞痛联合治疗中的现有证据。该综述表明,中成药作为常规抗心绞痛治疗的辅助治疗,在降低主要终点事件发生率、降低心绞痛发作率和改善心电图方面发挥着积极作用。此外,中成药已被证明相对安全。应进行进一步严格设计的临床试验以证实结果。