Second Ward of Cardiology Department, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China.
Department of Acupuncture and Moxibustion, Baicheng Medical College, Baicheng, China.
Medicine (Baltimore). 2022 Sep 2;101(35):e30394. doi: 10.1097/MD.0000000000030394.
This study assessed the effectiveness of Yangxin Decoction (YXD) in the treatment of coronary heart disease (CHD) patients with angina pectoris (AP).
In this study, we systematically and comprehensively searched the PUBMED, EMBASE, Cochrane Library, CNKI, WANGFANG, and VIP databases from their establishment to June 1, 2022. Clinical randomized controlled trials of YXD for the management of AP in patients with CHD were considered for inclusion. The outcomes included the response rate of AP, response rate based on electrocardiogram, and the rate of nitroglycerin use. Two authors independently performed literature selection, data extraction, and methodological quality assessment. Any differences were resolved by a third author through a discussion.
Nine trials involving 819 patients were included. The meta-analysis results showed that YXD significantly improved the response rate of AP (OR = 2.98, 95% CI: 1.96-4.55, I2 = 0%, P < .01) and the response rate based on the electrocardiogram (OR = 1.88, 95% CI: 1.28-2.78, I2 = 26%, P < .01), and significantly reduced the rate of nitroglycerin use (OR = 2.04, 95% CI: 1.19-3.52, I2 = 0%, P = .01).
The results of this study showed that YXD was effective in the treatment of patients with AP of CHD. Further studies are required to confirm these results.
本研究评估了养心汤（YXD）治疗冠心病心绞痛（AP）患者的疗效。
本研究系统全面地检索了 PUBMED、EMBASE、Cochrane 图书馆、CNKI、WANGFANG 和 VIP 数据库，检索时间从建库至 2022 年 6 月 1 日。纳入 YXD 治疗 CHD 患者 AP 的临床随机对照试验。结局指标包括 AP 缓解率、心电图缓解率和硝酸甘油使用率。两位作者独立进行文献筛选、数据提取和方法学质量评估。任何分歧均通过讨论由第三位作者解决。
纳入 9 项试验，共 819 例患者。Meta 分析结果显示，YXD 可显著提高 AP 缓解率（OR = 2.98，95%CI：1.96-4.55，I² = 0%，P <.01）和心电图缓解率（OR = 1.88，95%CI：1.28-2.78，I² = 26%，P <.01），显著降低硝酸甘油使用率（OR = 2.04，95%CI：1.19-3.52，I² = 0%，P =.01）。
本研究结果表明，YXD 对 CHD 患者的 AP 有效。需要进一步的研究来证实这些结果。
