Jiangxi University of Traditional Chinese Medicine.
The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi Province, PR China.
Medicine (Baltimore). 2021 Apr 23;100(16):e25608. doi: 10.1097/MD.0000000000025608.
As a common cardiovascular disease, the morbidity and mortality of coronary heart disease (CHD) are increasing year by year. In recent years, many RCTs have proved that compared with conventional therapy, the combination of TCMIs for promoting blood circulation and removing blood stasis can improve clinical efficacy. However, there is still a lack of direct comparative study between different kinds of TCMIs. Therefore, based on the NMA, this study compares the curative effects of various TCMIs for promoting blood circulation and removing blood stasis in treating CHD to provide a reference for clinical medication.
We will search PubMed, Web of Science, Embase, The Cochrane Library, China National Knowledge Infrastructure, The Chongqing VIP Chinese Science and Technology Periodic Database, Wanfang Database, and China Biomedical Literature Database for the randomized controlled trials of Danhong injection, Xuesaitong injection, Dengzhanxixin injection, and Salvianolate injection in the treatment of CHD, and we will also manually retrieve from the following databases: Chinese Clinical Trial Register, conference papers, and unpublished studies or references. According to the pre-established inclusion and exclusion criteria, 2 researchers independently screened the literature, extracted the data, and evaluated the RCTs' quality. The primary outcome indicators are the total effective rate of improving angina pectoris symptoms and electrocardiogram improvement. Secondary indicators were angina pectoris attack frequency, angina pectoris attack time, hemorheology, and inflammatory factor level. And use Stata 16.0 software for mesh meta-analysis. Evidence will be checked using the classification of recommendation, evaluation, development, and evaluation.
In this study, from the perspective of different kinds of TCMIs for promoting blood circulation and removing blood stasis, we will compare the curative effects of varying treatment measures and rank the curative effects.
This study will evaluate the efficacy of different kinds of TCMIs for promoting blood circulation and removing blood stasis in the treatment of CHD and help clinicians improve their clinical effectiveness.
INPLASY202130103.
冠心病作为一种常见的心血管疾病，其发病率和死亡率逐年上升。近年来，大量 RCT 已证实，相较于常规疗法，活血化瘀类中药注射剂联用能提高临床疗效。但不同活血化瘀类中药注射剂之间的疗效比较仍缺乏直接的对照研究。因此，本研究采用网状 Meta 分析方法，比较不同活血化瘀类中药注射剂治疗冠心病的疗效，以期为临床用药提供参考。
计算机检索 PubMed、Web of Science、Embase、The Cochrane Library、中国知网、维普中文科技期刊数据库、万方数据库、中国生物医学文献数据库，搜集丹红注射液、血塞通注射液、灯盏花素注射液、丹参多酚酸盐注射液治疗冠心病的随机对照试验，同时追溯纳入研究的参考文献、会议论文及补充材料。根据预先制定的纳入与排除标准，由 2 位研究者独立筛选文献、提取资料并评价纳入研究的质量，采用 Stata16.0 软件进行网状 Meta 分析。结局指标主要为心绞痛症状疗效总有效率、心电图疗效。次要结局指标为心绞痛发作频次、心绞痛发作时间、血液流变学、炎症因子水平。采用推荐、评估、制定与评价（Grading of Recommendations, Assessment, Development, and Evaluation，GRADE）系统对证据质量进行评价。
本研究从不同活血化瘀类中药注射剂的角度出发，比较不同治疗措施的疗效并进行排序。
本研究将对不同活血化瘀类中药注射剂治疗冠心病的疗效进行评价，有助于临床医师提高临床疗效。
INPLASY202130103.
