牙齿脱落与老年人轻度认知障碍发生之间的关联：藤原京研究

Association between tooth loss and the development of mild memory impairment in the elderly: the Fujiwara-kyo Study.

作者信息

Okamoto Nozomi, Morikawa Masayuki, Tomioka Kimiko, Yanagi Motokazu, Amano Nobuko, Kurumatani Norio

机构信息

Department of Community Health and Epidemiology, Nara Medical University, Japan.

Mie Prefectural Mental Care Center, Japan Department of Psychiatry, Nara Medical University, Japan.

出版信息

J Alzheimers Dis. 2015;44(3):777-86. doi: 10.3233/JAD-141665.

DOI:10.3233/JAD-141665

PMID:25362033

Abstract

BACKGROUND

Tooth loss may be a modifiable risk factor for memory disorders, but the causal relationship has not been evaluated sufficiently.

OBJECTIVE

This 5-year prospective cohort study investigated the effect of tooth loss on the development of mild memory impairment (MMI) among the elderly.

METHODS

Data are from the baseline and follow-up examinations of 2,335 community residents who were cognitively intact at baseline. The number of remaining teeth at baseline was classified as zero, 1-8, 9-16, 17-24, and 25-32. The main outcome for the analysis was the development of MMI at follow-up.

RESULTS

After adjustment for potential confounding factors in multivariable logistic regression analysis, the odds ratio of per 1 tooth loss at baseline was 1.02 (95% confidence interval, 1.00-1.03). The odds ratio of edentulism for MMI was 2.39 (1.48-3.86) compared to 25-32 teeth. The odds ratio of becoming edentulous compared to retaining 1-8 teeth in the 1-8 teeth group at baseline was 4.68 (1.50-14.58).

CONCLUSION

Tooth loss predicts the development of MMI among the elderly.

摘要

背景

牙齿缺失可能是记忆障碍的一个可改变的风险因素，但因果关系尚未得到充分评估。

目的

这项为期5年的前瞻性队列研究调查了牙齿缺失对老年人轻度记忆障碍（MMI）发生发展的影响。

方法

数据来自2335名基线时认知功能正常的社区居民的基线检查和随访检查。基线时剩余牙齿数量分为0颗、1 - 8颗、9 - 16颗、17 - 24颗和25 - 32颗。分析的主要结局是随访时MMI的发生。

结果

在多变量逻辑回归分析中对潜在混杂因素进行调整后，基线时每颗牙齿缺失的比值比为1.02（95%置信区间，1.00 - 1.03）。与有25 - 32颗牙齿相比，无牙对MMI的比值比为2.39（1.48 - 3.86）。在基线时1 - 8颗牙齿组中，与保留1 - 8颗牙齿相比，牙齿脱落的比值比为4.68（1.50 - 14.58）。