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联合使用结核分枝杆菌特异性CD4和CD8 T细胞应答是活动性结核病的一种强大诊断工具。

Combined use of Mycobacterium tuberculosis-specific CD4 and CD8 T-cell responses is a powerful diagnostic tool of active tuberculosis.

作者信息

Rozot Virginie, Patrizia Amelio, Vigano Selena, Mazza-Stalder Jesica, Idrizi Elita, Day Cheryl L, Perreau Matthieu, Lazor-Blanchet Catherine, Ohmiti Khalid, Goletti Delia, Bart Pierre-Alexandre, Hanekom Willem, Scriba Thomas J, Nicod Laurent, Pantaleo Giuseppe, Harari Alexandre

机构信息

Division of Immunology and Allergy, Lausanne University Hospital, Switzerland South African Tuberculosis Vaccine Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa.

Division of Immunology and Allergy, Lausanne University Hospital, Switzerland.

出版信息

Clin Infect Dis. 2015 Feb 1;60(3):432-7. doi: 10.1093/cid/ciu795. Epub 2014 Oct 31.

DOI:10.1093/cid/ciu795
PMID:25362202
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4293395/
Abstract

Immune-based assays are promising tools to help to formulate diagnosis of active tuberculosis. A multiparameter flow cytometry assay assessing T-cell responses specific to Mycobacterium tuberculosis and the combination of both CD4 and CD8 T-cell responses accurately discriminated between active tuberculosis and latent infection.

摘要

基于免疫的检测方法是有助于制定活动性结核病诊断的有前景的工具。一种评估针对结核分枝杆菌特异性T细胞反应以及CD4和CD8 T细胞反应组合的多参数流式细胞术检测方法能够准确区分活动性结核病和潜伏感染。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d2a/4293395/5d6ee3e8c1e2/ciu79502.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d2a/4293395/819286792794/ciu79501.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d2a/4293395/5d6ee3e8c1e2/ciu79502.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d2a/4293395/819286792794/ciu79501.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d2a/4293395/5d6ee3e8c1e2/ciu79502.jpg

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