Department of Bacteriology and Immunology, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China.
Department of Tuberculosis, Anhui Chest Hospital, Hefei 230022, China.
Medicina (Kaunas). 2022 Nov 7;58(11):1606. doi: 10.3390/medicina58111606.
This study was performed to investigate the association of peripheral T lymphocyte subsets with disseminated infection (DI) by (MTB) in HIV-negative patients. The study included 587 HIV-negative tuberculosis (TB) patients. In TB patients with DI, the proportion of CD4+ T cells decreased, the proportion of CD8+ T cells increased, and the ratio of CD4+/CD8+ T cells decreased. According to univariate analysis, smoking, alcohol consumption, rifampicin-resistance, retreatment, and high sputum bacterial load were linked to lower likelihood of developing MTB dissemination. Multivariate analysis indicated that after adjustment for alcohol use, smoking, retreatment, smear, culture, rifampicin-resistance, and CD4+/CD8+, the proportion of CD8+ T cells (but not CD4+ T cells) was independently and positively associated with the prevalence of DI in HIV-negative pulmonary TB (PTB) patients. Examining T lymphocyte subsets is of great value for evaluating the immune function of HIV-negative TB patients, and an increase in the CD8+ T cell proportion may be a critical clue regarding the cause of DI in such patients.
本研究旨在探讨外周血 T 淋巴细胞亚群与 HIV 阴性患者结核分枝杆菌（MTB）播散感染（DI）的相关性。研究纳入了 587 例 HIV 阴性结核病（TB）患者。在 DI 的 TB 患者中，CD4+T 细胞比例降低，CD8+T 细胞比例升高，CD4+/CD8+T 细胞比值降低。单因素分析显示，吸烟、饮酒、利福平耐药、复治和高痰菌载量与 MTB 播散发生的可能性降低有关。多因素分析表明，在调整了饮酒、吸烟、复治、涂片、培养、利福平耐药和 CD4+/CD8+后，CD8+T 细胞（而非 CD4+T 细胞）的比例与 HIV 阴性肺型结核（PTB）患者 DI 的患病率独立且呈正相关。检测 T 淋巴细胞亚群对于评估 HIV 阴性结核病患者的免疫功能具有重要价值，CD8+T 细胞比例的增加可能是此类患者 DI 病因的关键线索。
