微小RNA-31通过靶向E2F2促进结肠癌细胞增殖。
miR-31 promotes proliferation of colon cancer cells by targeting E2F2.
作者信息
Li Tong, Luo Wenjing, Liu Kunmei, Lv Xiaobo, Xi Tao
机构信息
School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, People's Republic of China,
出版信息
Biotechnol Lett. 2015 Mar;37(3):523-32. doi: 10.1007/s10529-014-1715-y. Epub 2014 Nov 2.
MicroRNA-31 (miR-31) plays important roles in colon cancer development. However, the underlying mechanism is still not clear. We have explored the functions of miR-31 on proliferation of colon cancer cells as well as the underlying mechanism. E2F2 was identified as a direct target of miR-31. miR-31 regulated the proliferation of colon cancer cells by targeting E2F2. Moreover, in the present study, E2F2 acted as a tumor suppressor in colon cancer by repressing the expression of survivin and regulating the expression of CCNA2, C-MYC, MCM4 and CDK2. A possible mechanism for the function of miR-31 on colon cancer proliferation is presented and indicates that miR-31 might become a target for anti-cancer drug design.
微小RNA-31（miR-31）在结肠癌发展过程中发挥着重要作用。然而，其潜在机制仍不清楚。我们探讨了miR-31对结肠癌细胞增殖的作用及其潜在机制。E2F2被确定为miR-31的直接靶点。miR-31通过靶向E2F2来调节结肠癌细胞的增殖。此外，在本研究中，E2F2通过抑制生存素的表达并调节细胞周期蛋白A2（CCNA2）、C-MYC、微小染色体维持蛋白4（MCM4）和细胞周期蛋白依赖性激酶2（CDK2）的表达，在结肠癌中起到肿瘤抑制作用。本文提出了miR-31对结肠癌增殖作用的一种可能机制，表明miR-31可能成为抗癌药物设计的靶点。
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