阿达木单抗诱发的皮下结节性结节病；肿瘤坏死因子-α抑制剂的一种罕见副作用。
Adalimumab Induced Subcutaneous Nodular Sarcoidosis; A Rare Side Effect of Tumor Necrosis Factor-α Inhibitor.
作者信息
Au Sonoa, Mirsaeidi Mehdi, Aronson Iris K, Sweiss Nadera J
机构信息
University of Illinois at Chicago.
出版信息
Sarcoidosis Vasc Diffuse Lung Dis. 2014 Oct 20;31(3):249-51.
Abstract
Adalimumab and other tumor necrosis factor-α inhibitors have been shown in the recent years to successfully treat sarcoidosis refractory to systemic corticosteroids and other agents. However, there have been an increasing number of cases of sarcoidosis paradoxically induced by these agents. It is hypothesized that this is due to the disruption of the fine balance of cytokines involved in granuloma formation. We describe the first case of adalimumab-induced subcutaneous nodular sarcoidosis in a patient with pulmonary sarcoidosis.
摘要
近年来，已证实阿达木单抗和其他肿瘤坏死因子-α抑制剂可成功治疗对全身用糖皮质激素和其他药物难治的结节病。然而，这些药物反常地诱发结节病的病例越来越多。据推测，这是由于肉芽肿形成过程中细胞因子的精细平衡被破坏所致。我们描述了首例在一名肺结节病患者中由阿达木单抗诱发的皮下结节性结节病病例。
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