Minnis P A, Poland M, Keane M P, Donnelly S C
School of Medicine and Medical Science, College of Life Sciences, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland.
National Pulmonary Fibrosis Referral Centre at St Vincent's University Hospital, Elm Park, Dublin, Ireland.
Ir J Med Sci. 2016 Nov;185(4):969-971. doi: 10.1007/s11845-015-1363-9. Epub 2015 Oct 1.
Ireland has one of the highest prevalence of sarcoidosis globally. Currently anti-TNF treatment in sarcoidosis is considered on a case-by-case basis particularly in patients who have a sub-optimal response to corticosteroid therapy.
We report our experience of Adalimumab in a series of refractory pulmonary sarcoidosis and discuss implications for treatment.
Symptomatic improvement was found in all patients as well as stabilisation or improvement in DLCO sb. Improvements in pulmonary function tests correlated well to radiological stage and length of disease.
爱尔兰是全球结节病患病率最高的国家之一。目前，结节病的抗TNF治疗是根据具体情况考虑的，特别是对于那些对皮质类固醇治疗反应欠佳的患者。
我们报告了阿达木单抗治疗一系列难治性肺结节病的经验，并讨论其对治疗的意义。
所有患者均出现症状改善，同时一氧化碳弥散量（DLCOsb）稳定或改善。肺功能测试的改善与放射学分期和病程长度密切相关。
