健康孕妇中抗心磷脂和β2-糖蛋白的免疫球蛋白M和免疫球蛋白G抗体水平的波动

Fluctuation in the Levels of Immunoglobulin M and Immunoglobulin G Antibodies for Cardiolipin and β2-Glycoprotein among Healthy Pregnant Women.

作者信息

Al-Balushi Mohammed S, Hasson Sidgi S, Said Elias A, Al-Busaidi Juma Z, Al-Daihani Muna S, Othman Mohammed S, Sallam Talal A, Idris Mohammed A, Al-Kalbani Moza, Woodhouse Nicholas, Al-Jabri Ali A

机构信息

Departments of Microbiology & Immunology, Sultan Qaboos University, Muscat, Oman;

Department of Community Health, Al Baha University, Al Baha, Saudi Arabia;

出版信息

Sultan Qaboos Univ Med J. 2014 Nov;14(4):e478-85. Epub 2014 Oct 14.

PMID:25364550

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4205059/

Abstract

OBJECTIVES

Antiphospholipid antibodies fluctuate during a healthy normal pregnancy. This study aimed to investigate the levels of both immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies for cardiolipin and β2-glycoprotein (β2GP) among healthy pregnant women.

METHODS

This study was conducted between May 2010 and December 2012. A total of 75 healthy Omani pregnant women with no history of autoimmune disease were investigated during their pregnancy and 90 days after delivery at the Armed Forces Hospital in Muscat, Oman. A control group of 75 healthy Omani non-pregnant women were also investigated as a comparison. Levels of IgM and IgG antibodies for both anti-cardiolipin antibodies (ACAs) and β2GP were measured using a standard enzyme-linked immunosorbent assay.

RESULTS

The ACA IgM levels were significantly higher in the control group compared to the pregnant women (P <0.001). No significant differences were observed in the ACA IgM levels between the control group and the pregnant women after delivery. In contrast, ACA IgG levels were significantly higher during pregnancy and after delivery compared with those of the healthy control group (P = 0.007 and 0.002, respectively). The levels of β2GP IgG were significantly higher during pregnancy than after delivery and in the control group (P = 0.001 and <0.001, respectively).

CONCLUSION

In this study, ACA IgG levels increased during healthy pregnancies and after normal deliveries whereas β2GP IgG levels increased transiently during the pregnancies. Both phenomena were found to be significantly associated with a transient decline in the levels of IgM specific for these antigens. Therefore, the levels of these antibodies may be regulated during a healthy pregnancy.

摘要

目的

抗磷脂抗体在健康正常妊娠期间会发生波动。本研究旨在调查健康孕妇中抗心磷脂和β2糖蛋白（β2GP）的免疫球蛋白M（IgM）和免疫球蛋白G（IgG）抗体水平。

方法

本研究于2010年5月至2012年12月进行。共对75名无自身免疫性疾病史的阿曼健康孕妇在孕期及产后90天于阿曼马斯喀特的武装部队医院进行了调查。还对75名阿曼健康非孕妇组成的对照组进行了调查作为比较。使用标准酶联免疫吸附测定法测量抗心磷脂抗体（ACA）和β2GP的IgM和IgG抗体水平。

结果

对照组的ACA IgM水平显著高于孕妇（P<0.001）。对照组与产后孕妇的ACA IgM水平未观察到显著差异。相比之下，孕期和产后的ACA IgG水平均显著高于健康对照组（分别为P = 0.007和0.002）。β2GP IgG水平在孕期显著高于产后及对照组（分别为P = 0.001和<0.001）。