Blanco P J, Trenhago P R, Fernandes L G, Feijóo R A
Laboratório Nacional de Computação Científica, Av. Getúlio Vargas 333, Quitandinha, 25651-075, Petrópolis, Brazil; Instituto Nacional de Ciência e Tecnologia em Medicina Assistida por Computação Científica, Petrópolis, Brazil.
Int J Numer Method Biomed Eng. 2012 Apr;28(4):412-33. doi: 10.1002/cnm.1474. Epub 2011 Nov 2.
The aim of the present work is to describe the integration of a mathematical model for the baroreceptor reflex mechanism to provide regulatory action into a dimensionally heterogeneous (3D-1D-0D) closed-loop model of the cardiovascular system. Such heterogeneous model comprises a 1D description of the arterial tree, a 0D network for the venous, cardiac and pulmonary circulations and 3D patient-specific geometries for vascular districts of interest. Thus, the detailed topological description of the arterial network allows us to perform vasomotor control actions in a differentiated way, while gaining insight about the effects of the baroreflex regulation over hemodynamic quantities of interest throughout the entire network. Two examples of application are presented. Firstly, we simulate the hemorrhage in the abdominal aorta artery and analyze the action of the baroreflex over the system. Secondly, the self-regulated closed-loop model is applied to study the influence of the control action in the hemodynamic environment that determines the blood flow pattern in a cerebral aneurism in the presence of a regurgitating aortic valve.
本研究的目的是描述将压力感受器反射机制的数学模型整合到心血管系统的尺寸异构（3D-1D-0D）闭环模型中，以提供调节作用。这种异构模型包括动脉树的一维描述、静脉、心脏和肺循环的零维网络以及感兴趣血管区域的三维患者特异性几何形状。因此，动脉网络的详细拓扑描述使我们能够以差异化的方式执行血管舒缩控制动作，同时深入了解压力反射调节对整个网络中感兴趣的血流动力学量的影响。给出了两个应用示例。首先，我们模拟腹主动脉出血并分析压力反射对系统的作用。其次，将自调节闭环模型应用于研究在存在主动脉瓣反流的情况下，控制作用对决定脑动脉瘤血流模式的血流动力学环境的影响。
