Yakushiji Yusuke, Horikawa Etsuo, Eriguchi Makoto, Nanri Yusuke, Nishihara Masashi, Hirotsu Tatsumi, Hara Hideo
Division of Neurology, Department of Internal Medicine, Saga University Faculty of Medicine, Japan.
Intern Med. 2014;53(21):2447-53. doi: 10.2169/internalmedicine.53.2683. Epub 2014 Nov 1.
The distribution of the Mini-Mental State Examination (MMSE) scores by age and educational level was investigated in subjects that underwent comprehensive brain examinations.
This cross-sectional study included 1,414 adults without neurological disorders who underwent health-screening tests of the brain, referred to as the "Brain Dock," in our center. The MMSE scores were compared between age groups (40-44, 45-49, 50-54, 55-59, 60-64, 65-69, or ≥70 years) and educational levels [the low education level group (6-12 years) and the high education level group (≥13 years)].
The median age was 59 years, and 763 (54%) were women. There was no significant difference in the MMSE total score between women and men. The stepwise method of the multiple linear regression analysis confirmed that a higher age [β value, -0.129; standard error (S.E.), 0.020; p<0.001], low education level (6-12 years) (β value, -0.226; S.E., 0.075; p=0.003), and women (β values, 0.148; S.E., 0.066; p=0.024) was significantly associated with decreased MMSE score. In general, both the percentile scores and mean scores decreased with aging and were lower in the low education level group than in the high education level group. The degree of decrement in scores with age was stronger in the low education level group than in the high education level group.
The provided data for age- and education-specific reference norms will be useful for both clinicians and investigators who perform comprehensive brain examinations to assess the cognitive function of subjects.
在接受全面脑部检查的受试者中，研究简易精神状态检查表（MMSE）得分按年龄和教育水平的分布情况。
这项横断面研究纳入了1414名无神经系统疾病的成年人，他们在我们中心接受了脑部健康筛查测试，即“脑部检查”。比较了不同年龄组（40 - 44岁、45 - 49岁、50 - 54岁、55 - 59岁、60 - 64岁、65 - 69岁或≥70岁）和不同教育水平组[低教育水平组（6 - 12年）和高教育水平组（≥13年）]的MMSE得分。
中位年龄为59岁，女性有763名（54%）。女性和男性的MMSE总分无显著差异。多元线性回归分析的逐步法证实，年龄较大[β值，-0.129；标准误（S.E.），0.020；p<0.001]、低教育水平（6 - 12年）（β值，-0.226；S.E.，0.075；p = 0.003）以及女性（β值，0.148；S.E.，0.066；p = 0.024）与MMSE得分降低显著相关。总体而言，百分位数得分和平均分均随年龄增长而降低，且低教育水平组低于高教育水平组。低教育水平组得分随年龄的下降程度比高教育水平组更强。
所提供的按年龄和教育水平划分的参考规范数据，对于进行全面脑部检查以评估受试者认知功能的临床医生和研究人员均有用处。
