Akbari Iman, Ghoreishi Seyyed M, Habibi Neda
Department of Chemical Engineering, Isfahan University of Technology, 84156-83111, Isfahan, Iran.
AAPS PharmSciTech. 2015 Apr;16(2):428-34. doi: 10.1208/s12249-014-0212-x. Epub 2014 Oct 31.
Plant-derived polymers are widely used in the pharmaceutical industry due to their emollient, lack of toxicity, and irritating nature and low cost. In this work, basil seed mucilage was dried using supercritical carbon dioxide phase inversion technique to form a nanometric structure. The obtained polymeric structures were characterized by scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) method, and Fourier transform infrared spectroscopy (FTIR) and compared with the oven-derived sample group. It was demonstrated that the product morphology could be controlled by altering the composition of methanol which functioned as the co-solvent in the nonsolvent stream. The most homogeneous product (60-nm mean pore size diameter, 78 m(2)/g BET surface area with no agglomeration) was obtained with 2.5% methanol. The FTIR data showed that the presence of hydroxyl and carboxyl groups suggested the bioadhesive property of basil seed mucilage was good and many active pharmaceutical compounds might be loaded to the resultant nanometric structure to enhance drug release. Furthermore, the FTIR analyses indicated that the nature of the final product did not change during the supercritical drying procedure.
植物源聚合物因其具有润肤性、无毒性、刺激性小且成本低等特点，在制药行业中得到广泛应用。在本研究中，采用超临界二氧化碳相转变技术对罗勒籽黏液进行干燥，以形成纳米结构。通过扫描电子显微镜（SEM）、布鲁诺尔-埃米特-泰勒（BET）法和傅里叶变换红外光谱（FTIR）对所得聚合物结构进行表征，并与烘箱干燥样品组进行比较。结果表明，通过改变在非溶剂流中作为助溶剂的甲醇组成，可以控制产品形态。使用2.5%的甲醇可获得最均匀的产品（平均孔径直径为60纳米，BET表面积为78平方米/克，无团聚现象）。FTIR数据表明，羟基和羧基的存在表明罗勒籽黏液的生物黏附性良好，许多活性药物化合物可能被负载到所得纳米结构中以增强药物释放。此外，FTIR分析表明，最终产品的性质在超临界干燥过程中没有改变。
