Reboul Emmanuelle
INRA, UMR 1260, "Nutrition, Obesity and Risk of Thrombosis", F-13385, Marseille, France.
Food Funct. 2015 Feb;6(2):356-62. doi: 10.1039/c4fo00579a.
Vitamin D plays key roles in bone, infectious, inflammatory and metabolic diseases. As most people get inadequate sun exposure for sufficient vitamin D status, they need adequate intake of dietary vitamin D. Many studies see optimizing vitamin D status as a public health priority. It is thus vital to gain deeper insight into vitamin D intestinal absorption. It was long assumed that vitamin D intestinal absorption is a passive process, but new data from our laboratory showed that it is actually far more complex than previously thought. This review describes the fate of vitamin D in the human upper gastrointestinal lumen during digestion and focuses on the proteins involved in the intestinal membrane and cellular transport of vitamin D across the enterocyte. Although recent data significantly improve our understanding of vitamin D intestinal absorption, further studies are still needed to increase our knowledge of the molecular mechanisms underlying this phenomenon.
维生素D在骨骼、感染性、炎症性和代谢性疾病中发挥着关键作用。由于大多数人日照不足，无法获得充足的维生素D状态，因此他们需要从饮食中摄入足够的维生素D。许多研究将优化维生素D状态视为公共卫生的优先事项。因此，深入了解维生素D的肠道吸收至关重要。长期以来，人们一直认为维生素D的肠道吸收是一个被动过程，但我们实验室的新数据表明，它实际上比之前认为的要复杂得多。这篇综述描述了维生素D在人类上消化道消化过程中的命运，并重点关注参与维生素D穿过肠细胞的肠膜和细胞转运的蛋白质。尽管最近的数据显著提高了我们对维生素D肠道吸收的理解，但仍需要进一步研究以增加我们对这一现象潜在分子机制的认识。
