Kang Ji Yeon, Sung Sook Hee, Lee Yeon Ju, Choi Tae In, Choi Seung Jin
Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd., Seoul, Korea.
Central Research Institute, Korea Hydro & Nuclear Power Co., Ltd., Daejeon, Korea.
J Korean Med Sci. 2014 Oct;29(10):1353-9. doi: 10.3346/jkms.2014.29.10.1353. Epub 2014 Oct 8.
Ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) gene has been studied in relation to type 2 diabetes mellitus (T2DM) and insulin resistance (IR). We hypothesized that the difference in genotype may be one of the factors that affect the outcome of intervention. We genotyped 448 men with fasting glucose≥5.6 mM/L, including 371 in subjects with K allele (KK) (69 control group [CG]; and 302 intervention group [IG]) and 77 in subjects with Q allele (KQ+QQ) (13 CG and 64 IG). The web-based intervention based on a lifestyle modification was delivered by e-mail once a month for 10 months. In the KK, IG demonstrated significantly decreased levels of fasting serum insulin (FSI) as compared to CG and homeostasis model of assessment of insulin resistance (HOMA-IR). In the KQ+QQ IG group, hemoglobin A1c (HbA1c), FSI and HOMA-IR were significantly decreased, and showed further reduction in the HOMA-IR than KQ+QQ CG. After analysis of covariance, K121Q did significantly influence the change of HbA1c in CG after appropriate adjustment. In a multivariate model, BMI change predicted HOMA-IR change (adjusted β=0.801; P=0.022) in KK IG subjects with T2DM. ENPP1 K121Q did not influence the change in IR. However, individuals with T2DM carrying the K121 variant are very responsive to the effect of BMI reduction on HOMA-IR.
已对胞外核苷酸焦磷酸磷酸二酯酶1（ENPP1）基因与2型糖尿病（T2DM）和胰岛素抵抗（IR）的关系进行了研究。我们推测基因型差异可能是影响干预结果的因素之一。我们对448名空腹血糖≥5.6 mM/L的男性进行了基因分型，其中371名携带K等位基因（KK）（69名对照组[CG]；302名干预组[IG]），77名携带Q等位基因（KQ + QQ）（13名CG和64名IG）。基于生活方式改变的网络干预通过电子邮件每月发送一次，持续10个月。在KK组中，与CG相比，IG组的空腹血清胰岛素（FSI）水平和胰岛素抵抗稳态模型评估（HOMA-IR）显著降低。在KQ + QQ IG组中，糖化血红蛋白（HbA1c）、FSI和HOMA-IR显著降低，且HOMA-IR的降低幅度比KQ + QQ CG组更大。经过协方差分析，在适当调整后，K121Q确实显著影响了CG组中HbA1c的变化。在多变量模型中，BMI变化预测了T2DM的KK IG受试者中HOMA-IR的变化（调整后β = 0.801；P = 0.022）。ENPP1 K121Q不影响IR的变化。然而，携带K121变体的T2DM个体对BMI降低对HOMA-IR的影响非常敏感。
