与中年非肥胖农村人群胰岛素抵抗相关的因素：忠州代谢性疾病队列研究（CMC 研究）。
Factors Associated with Insulin Resistance in a Middle-Aged Non-Obese Rural Population: The Chungju Metabolic Disease Cohort (CMC) Study.
机构信息
Graduate School of Public Health, The Catholic University of Korea, Seoul, Korea.
出版信息
Epidemiol Health. 2011;33:e2011009. doi: 10.4178/epih/e2011009. Epub 2011 Sep 26.
OBJECTIVES
We aimed to determine the characteristics affecting insulin resistance in non-obese middle-aged adults in a rural community.
METHODS
A total of 1,270 non-diabetic adults aged between 40 and 64 years old with body mass index (BMI) less than 25 kg/m(2) were analyzed. Subjects with insulin resistance were defined as those who had the highest quartile value of the homeostasis model assessment of insulin resistance (HOMA-IR) in a non-diabetic population.
RESULTS
A total of 217 subjects (20.6%) had insulin resistance. Prevalence of metabolic syndrome was significantly higher in insulin-resistant subjects in both men (29.3% vs. 10.3%) and women (34.1% vs. 15.6%). Among metabolic syndrome components, elevated waist circumference and elevated triglyceride were higher in insulin-resistant subjects in both genders. After being controlled for socioeconomic status and lifestyle related covariates, the association between insulin resistance and BMI was statistically significant in the category of 23.0-24.9 kg/m(2) in men (adjusted OR, 4.63; 95% confidence interval [95% CI], 1.77-12.15) using the category of 18.5-20.9 kg/m(2) as a reference. In addition, the association between insulin resistance and abdominal obesity was statistically significant only for men (adjusted OR, 2.57; 95% CI, 1.29-5.11).
CONCLUSION
Insulin resistance appears to be highly associated with high BMI and abdominal obesity, even in non-obese, non-diabetic middle-aged men.
目的
我们旨在确定农村社区中非肥胖中年成年人胰岛素抵抗的影响因素。
方法
共分析了 1270 名年龄在 40 至 64 岁之间、BMI（体重指数）<25kg/m²且无糖尿病的成年人。胰岛素抵抗者定义为在非糖尿病人群中，稳态模型评估的胰岛素抵抗（HOMA-IR）最高四分位值的人群。
结果
共有 217 名（20.6%）受试者存在胰岛素抵抗。在男性（29.3%比 10.3%）和女性（34.1%比 15.6%）中，胰岛素抵抗者的代谢综合征患病率均显著更高。在代谢综合征的各项指标中，男性和女性胰岛素抵抗者的腰围增大和甘油三酯升高比例均较高。在控制了社会经济地位和与生活方式相关的混杂因素后，男性 BMI 在 23.0-24.9kg/m² 范围内与胰岛素抵抗的相关性具有统计学意义（调整后的 OR，4.63；95%置信区间[95%CI]，1.77-12.15），以 18.5-20.9kg/m² 为参照。此外，仅在男性中，胰岛素抵抗与腹型肥胖之间存在统计学显著关联（调整后的 OR，2.57；95%CI，1.29-5.11）。
结论
即使在非肥胖、非糖尿病的中年男性中，胰岛素抵抗似乎与高 BMI 和腹型肥胖高度相关。
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