Laboratory of Organic Chemistry, ETH Zurich , Vladimir-Prelog-Weg 3, CH-8093 Zurich, Switzerland.
J Am Chem Soc. 2014 Nov 12;136(45):15829-32. doi: 10.1021/ja507405j. Epub 2014 Nov 4.
The first crystal structure of an oligoproline adopting an all-trans polyproline II (PPII) helix is presented. The high-resolution structure provides detailed insight into the dimensions and conformational properties of oligoprolines that are important for, e.g., their use as "molecular rulers" and "molecular scaffolds". The structure also showed that the amides interact with each other within a PPII helix and that water is not necessary for PPII helicity.
首次呈现出一个采用全反式聚脯氨酸 II（PPII）螺旋的寡聚脯氨酸的晶体结构。该高分辨率结构提供了有关寡聚脯氨酸的尺寸和构象特性的详细信息，这些特性对于它们作为“分子标尺”和“分子支架”的用途等方面非常重要。该结构还表明，酰胺在 PPII 螺旋内相互作用，并且 PPII 螺旋的形成不需要水。
