趋化因子信号传导在发育与疾病中的作用
Chemokine signaling in development and disease.
作者信息
Wang John, Knaut Holger
机构信息
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University Langone Medical Center, New York, NY 10016, USA.
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University Langone Medical Center, New York, NY 10016, USA Kimmel Center for Stem Cell Biology, New York University Langone Medical Center, New York, NY 10016, USA
出版信息
Development. 2014 Nov;141(22):4199-205. doi: 10.1242/dev.101071.
Abstract
Chemokines are a group of small, secreted molecules that signal through G protein-coupled receptors to promote cell survival and proliferation and to provide directional guidance to migrating cells. CXCL12 is one of the most evolutionary conserved chemokines and signals through the chemokine receptor CXCR4 to guide cell migration during embryogenesis, immune cell trafficking and cancer metastasis. Here and in the accompanying poster, we provide an overview of chemokine signaling, focusing on CXCL12, and we highlight some of the different chemokine-dependent strategies used to guide migrating cells.
摘要
趋化因子是一类小的分泌分子，它们通过G蛋白偶联受体发出信号，以促进细胞存活和增殖，并为迁移的细胞提供定向引导。CXCL12是进化上最保守的趋化因子之一，它通过趋化因子受体CXCR4发出信号，在胚胎发育、免疫细胞运输和癌症转移过程中引导细胞迁移。在本文以及随附的海报中，我们概述了趋化因子信号传导，重点是CXCL12，并强调了一些用于引导迁移细胞的不同的趋化因子依赖性策略。
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