Ljungman C, Kahan T, Schiöler L, Hjerpe P, Wettermark B, Boström K B, Manhem K
Institute of Medicine, Department of Molecular and Clinical Medicine/Cardiology, Sahlgrenska University Hospital, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.
Karolinska Institutet, Department of Clinical Sciences, Danderyd Hospital, Division of Cardiovascular Medicine, Stockholm, Sweden.
J Hum Hypertens. 2015 Jun;29(6):385-93. doi: 10.1038/jhh.2014.100. Epub 2014 Nov 6.
The reasons why women and men are treated with different antihypertensive drugs are not clear. Whether socioeconomic factors influence prescription patterns and blood pressure control differently in women and men has not been investigated. This cross-sectional study performed in a cohort of hypertensive patients from the Swedish Primary Care Cardiovascular Database (SPCCD) examined the influence of educational level, country of birth, gender and concomitant psychiatric disorder on prescription pattern and blood pressure control in 40,825 hypertensive patients. Men were more often than women treated with calcium channel blocker and angiotensin-converting enzyme inhibitor (ACEI), irrespective of education, country of birth and psychiatric disorder. Educational level influenced the prescription pattern to some extent, where the gender differences were reduced in patients with a higher educational level. In women, but not in men, high educational level and concomitant psychiatric disorder were associated with a higher proportion reaching target blood pressure. The predominant use of ACEI and calcium channel blockers in men is not influenced by educational level, country of birth or psychiatric disorder. Thus other explanations must be considered such as gender differences in side effects. Educational level seems to have a greater impact on reaching target blood pressure in women compared with men.
女性和男性使用不同抗高血压药物治疗的原因尚不清楚。社会经济因素对女性和男性的处方模式及血压控制的影响是否不同,尚未得到研究。这项横断面研究在瑞典初级保健心血管数据库(SPCCD)的一组高血压患者中进行,调查了教育水平、出生国家、性别和伴发的精神障碍对40825名高血压患者的处方模式和血压控制的影响。无论教育程度、出生国家和精神障碍如何,男性比女性更常使用钙通道阻滞剂和血管紧张素转换酶抑制剂(ACEI)。教育水平在一定程度上影响处方模式,在教育水平较高的患者中,性别差异有所减小。在女性中,而非男性中,高教育水平和伴发的精神障碍与达到目标血压的比例较高相关。男性中ACEI和钙通道阻滞剂的主要使用不受教育水平、出生国家或精神障碍的影响。因此,必须考虑其他解释,如副作用方面的性别差异。与男性相比,教育水平似乎对女性达到目标血压有更大影响。