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2
Breastfeeding protects against current asthma up to 6 years of age.母乳喂养可预防当前哮喘，直至 6 岁。
J Pediatr. 2012 Jun;160(6):991-6.e1. doi: 10.1016/j.jpeds.2011.11.055. Epub 2012 Jan 30.
3
Breast feeding, parental allergy and asthma in children followed for 8 years. The PIAMA birth cohort study.母乳喂养、父母过敏与儿童哮喘：一项为期8年的跟踪研究。PIAMA出生队列研究
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4
Effect of prolonged and exclusive breast feeding on risk of allergy and asthma: cluster randomised trial.长期纯母乳喂养对过敏和哮喘风险的影响：整群随机试验
BMJ. 2007 Oct 20;335(7624):815. doi: 10.1136/bmj.39304.464016.AE. Epub 2007 Sep 11.
5
Breastfeeding and hospitalization for diarrheal and respiratory infection in the United Kingdom Millennium Cohort Study.英国千禧队列研究中母乳喂养与腹泻及呼吸道感染住院情况
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6
Breastfeeding does not increase the risk of asthma at 14 years.母乳喂养不会增加14岁时患哮喘的风险。
Pediatrics. 2006 Apr;117(4):e787-92. doi: 10.1542/peds.2005-1753.
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Atopic disease and breast-feeding--cause or consequence?特应性疾病与母乳喂养——原因还是结果？
J Allergy Clin Immunol. 2006 Mar;117(3):682-7. doi: 10.1016/j.jaci.2005.10.027. Epub 2006 Feb 15.
8
The role of breast-feeding in the development of allergies and asthma.母乳喂养在过敏和哮喘发展中的作用。
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9
A review of the effects of breastfeeding on respiratory infections, atopy, and childhood asthma.母乳喂养对呼吸道感染、特应性和儿童哮喘影响的综述。
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Breast-feeding reduces the risk of asthma during the first 4 years of life.母乳喂养可降低儿童出生后前4年患哮喘的风险。
J Allergy Clin Immunol. 2004 Oct;114(4):755-60. doi: 10.1016/j.jaci.2004.07.036.

母乳喂养与幼儿期哮喘住院治疗：日本一项全国性纵向调查

Breast-feeding and hospitalization for asthma in early childhood: a nationwide longitudinal survey in Japan.

作者信息

Yamakawa Michiyo, Yorifuji Takashi, Kato Tsuguhiko, Yamauchi Yoshitada, Doi Hiroyuki

机构信息

1Center for Regional Research,Okayama University,3-1-1 Tsushima-naka,Kita-ku,Okayama 700-8530,Japan.

2Department of Human Ecology,Okayama University Graduate School of Environmental and Life Science,Okayama,Japan.

出版信息

Public Health Nutr. 2015 Jul;18(10):1756-61. doi: 10.1017/S1368980014002407. Epub 2014 Nov 6.

DOI:10.1017/S1368980014002407
PMID:25373365
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10271718/
Abstract

OBJECTIVE

Whether or not breast-feeding is protective against asthma among children is still controversial. Therefore, we examined the effects of breast-feeding on hospitalization for asthma in early childhood.

DESIGN

Secondary data analyses of a nationwide longitudinal survey of children in Japan ongoing since 2001, with results collected from 2001 to 2004. We used logistic regression models to evaluate the associations of breast-feeding with hospitalization for asthma in children between the ages of 6 and 42 months, adjusting for children's factors (sex, day-care attendance and presence of older siblings) and maternal factors (educational attainment and smoking habit). Setting All over Japan.

SUBJECTS

Term singleton children with information on feeding practices during infancy (n 43367).

RESULTS

After adjusting for maternal factors and children's factors, exclusive breast-feeding at 6-7 months of age was associated with decreased risk of hospitalization for asthma in children. The adjusted odds ratio was 0.77 (95% CI 0.56, 1.06). One-month longer duration of breast-feeding was associated with a 4% decreased risk of hospitalization for asthma (OR = 0.96; 95% CI 0.92, 0.99).

CONCLUSIONS

The protective effects of breast-feeding on hospitalization for asthma were observed in children between the ages of 6 and 42 months.

摘要

目的

母乳喂养对儿童哮喘是否具有预防作用仍存在争议。因此，我们研究了母乳喂养对幼儿哮喘住院率的影响。

设计

对自2001年起在日本全国范围内开展的一项针对儿童的纵向调查进行二次数据分析，数据收集时间为2001年至2004年。我们使用逻辑回归模型来评估母乳喂养与6至42个月大儿童哮喘住院之间的关联，并对儿童因素（性别、是否参加日托以及是否有哥哥姐姐）和母亲因素（教育程度和吸烟习惯）进行了调整。研究地点为日本全国。

研究对象

有婴儿期喂养方式信息的足月单胎儿童（n = 43367）。

结果

在对母亲因素和儿童因素进行调整后，6至7个月时纯母乳喂养与儿童哮喘住院风险降低相关。调整后的优势比为0.77（95%可信区间为0.56, 1.06）。母乳喂养时间每延长一个月，哮喘住院风险降低4%（优势比 = 0.96；95%可信区间为0.92, 0.99）。

结论

在6至42个月大的儿童中观察到母乳喂养对哮喘住院具有预防作用。